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Regional brain gray matter abnormalities in patients with bipolar II disorder: A comparison study with bipolar I patients and healthy controls

Cited 64 time in Web of Science Cited 71 time in Scopus
Authors
Ha, Tae Hyon; Ha, Kyooseob; Kim, Jae Hyoung; Choi, Jung Eun
Issue Date
2009-05-29
Publisher
ELSEVIER IRELAND LTD
Citation
NEUROSCIENCE LETTERS; Vol.456(1); 44-48
Keywords
Bipolar disorderVentromedial prefrontal cortexMRIVoxel-based morphometry
Abstract
Despite the high prevalence and clinical significance of bipolar II disorder (BD II), the underlying pathophysiology is not well explored in previous studies. The purpose of the current study was to investigate brain gray matter abnormalities in BD II. High resolution magnetic resonance brain images from 23 BD II patients, 23 sex- and age-matched patients with bipolar I disorder (BD I) and 23 healthy controls were acquired and processed according to the optimized voxel-based morphometry protocol. The processed gray matter tissue volumes were compared among the three groups. Both the BD II and BD I group showed gray matter deficits in the ventromedial prefrontal regions, compared to controls. The BD I group had widespread gray matter reductions in the bilateral frontal, temporal, parietal and parahippocampal cortices, compared to controls. However, gray matter reductions in these regions were not found in the BD II group. With a less conservative statistical threshold, the BD II group showed additional gray matter deficits in the anterior limbic cortices. Our data suggest that gray matter deficits in the ventromedial prefrontal and anterior limbic cortices are common in both BD II and BD I. On the other hand, different pattern of gray matter abnormalities between BY II and BD I found in this study supports that two subtypes may have different neurobiological characteristics.
ISSN
0304-3940
Language
English
URI
http://hdl.handle.net/10371/78561
DOI
https://doi.org/10.1016/j.neulet.2009.03.077
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College of Medicine/School of Medicine (의과대학/대학원)Psychiatry (정신과학전공)Journal Papers (저널논문_정신과학전공)
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