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Thymosin beta 4 enhances NK cell cytotoxicity mediated by ICAM-1

Cited 11 time in Web of Science Cited 12 time in Scopus
Authors
Lee, Ha-reum; Yoon, Sun Young; Kang, Ho-Bum; Park, Sunyoung; Cho, Young Hoon; Kim, Chul-woo; Lee, Wang Jae; Park, Hyunjeong; Cho, Daeho; Bang, Sa Ik; Cho, Byung Joo; Kim, Seonghan; Kim, Kyung-Eun
Issue Date
2009-03-24
Publisher
ELSEVIER SCIENCE BV
Citation
IMMUNOLOGY LETTERS; Vol.123(1); 72-76
Keywords
Thymosin beta 4NK cell cytotoxicityICAM-1
Abstract
Thymosin beta 4 (T beta 4), which is the major G-actin sequestering protein, has been shown to have ubiquitous distribution and multiple biological activities. However, T beta 4`s functions in relation to natural killer (NK) cells are still unknown. In this study, we show that synthetic T beta 4 peptide increases NK cell cytotoxicity mediated by intercellular adhesion molecule-1 (ICAM-1) through the secretion of cytolytic granules to target cells. This suggests that T beta 4 is a key activator of NK cell cytotoxicity.
ISSN
0165-2478
Language
English
URI
http://hdl.handle.net/10371/78667
DOI
https://doi.org/10.1016/j.imlet.2009.02.008
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College of Medicine/School of Medicine (의과대학/대학원)Anatomy (해부학전공)Journal Papers (저널논문_해부학전공)
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