Browse

Immunohistochemical localization of insulin-like growth factor binding protein 2 in the central nervous system of SOD1(G93A) transgenic mice

Cited 2 time in Web of Science Cited 2 time in Scopus
Authors
Sim, Sung Eun; Chung, Yoon Hee; Jeong, Ji Hoon; Yun, Sin Weon; Kim, Daejin; Lee, Won Bok; Cha, Choong Ik; Kim, Sung Su; Lim, Hyoun-Sub
Issue Date
2009-04
Publisher
SPRINGER
Citation
JOURNAL OF MOLECULAR HISTOLOGY; Vol.40, No.2; 157-163
Keywords
Amyotrophic lateral sclerosis (ALS)SOD1(G93A) transgenic miceImmunohistochemistryHippocampusCerebral cortexInsulin-like growth factor binding protein 2 (IGFBP2)
Abstract
In the present study, we performed immunohistochemical studies to investigate the changes of insulin-like growth factor binding protein 2 (IGFBP2) in the central nervous system of SOD1(G93A) mutant transgenic mice as an in vivo model of amyotrophic lateral sclerosis (ALS). Decreased immunoreactivity for IGFBP2 was observed in the cerebral cortex, hippocampus and brainstem of SOD1(G93A) transgenic mice. In the cerebral cortex, the number of IGFBP2-positive cells was decreased in the somatomotor area, somatosensory area, auditory area, visual area, entorhinal area, piriform area and prefrontal area. In the hippocampal formation, IGFBP2 immunoreactivity was significantly decreased in the CA1-3 areas and the dentate gyrus. In the brainstem, few IGFBP2-immunoreactive cells were observed in the medullary and pontine reticular formation, vestibular nucleus, trigeminal motor nucleus, facial nucleus, hypoglossal nucleus and raphe nucleus. In the spinal cord, IGFBP2 immunoreactivity was not significantly decreased in SOD1(G93A) transgenic mice. This study showing decreased IGFBP2 in different brain regions of SOD1(G93A) transgenic mice may provide clues for understanding differential susceptibility of neural structures in ALS.
ISSN
1567-2379
Language
English
URI
http://hdl.handle.net/10371/78670
DOI
https://doi.org/10.1007/s10735-009-9219-0
Files in This Item:
There are no files associated with this item.
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Anatomy (해부학전공)Journal Papers (저널논문_해부학전공)
  • mendeley

Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse