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Expression of Adenomatous Polyposis Coli Protein in Reactive Astrocytes in Hippocampus of Kainic Acid-Induced Rat

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dc.contributor.authorLee, Ha Na-
dc.contributor.authorJeon, Gye Sun-
dc.contributor.authorKim, Dong Woon-
dc.contributor.authorCho, Ik-Hyun-
dc.contributor.authorCho, Sa Sun-
dc.date.accessioned2012-07-10T01:22:30Z-
dc.date.available2012-07-10T01:22:30Z-
dc.date.issued2010-01-
dc.identifier.citationNEUROCHEMICAL RESEARCH; Vol.35, No.1; 114-121ko_KR
dc.identifier.issn0364-3190-
dc.identifier.urihttp://hdl.handle.net/10371/78681-
dc.description.abstractThe adenomatous polyposis coli gene (APC) was initially identified through its link to colon cancer. It is associated with the regulation of cell cycle progression, survival, and differentiation of normal tissues. Recent studies have demonstrated that APC is also expressed in the adult brain at high levels. However, its role in glial cells under pathological progression remains unclear. In this study, we evaluated the expression of APC and its association with beta-catenin signaling pathway, following the induction of an excitotoxic lesion by kainic acid (KA) injection, which cause pyramidal cell degeneration. APC was predominantly present in oligodendrocytes in the normal brain, but was specifically associated with activated astrocytes in the KA-treated brain. Our quantitative analysis revealed that APC significantly increased from 1 day post lesion (PI), reached peak values at 3 days PI, and decreased thereafter. The phospho-GSK3 beta levels also showed similar spatiotemporal patterns while beta-catenin expression was reduced at 1 and then increasingly returned to normal levels at 3, 7 days PI. For the first time, our data demonstrate the injury-induced astrocytic changes in the levels of APC, GSK3 beta, and beta-catenin in vivo, which may actively be participate in cell adhesion and in the signaling pathway regulating cell survivals during brain insults.ko_KR
dc.language.isoenko_KR
dc.publisherSPRINGER/PLENUM PUBLISHERSko_KR
dc.subjectAdenomatous polyposis coliko_KR
dc.subjectBeta-cateninko_KR
dc.subjectKainic acidko_KR
dc.subjectGSK-3betako_KR
dc.subjectAstrocytesko_KR
dc.subjectOligodendrocytesko_KR
dc.titleExpression of Adenomatous Polyposis Coli Protein in Reactive Astrocytes in Hippocampus of Kainic Acid-Induced Ratko_KR
dc.typeArticleko_KR
dc.contributor.AlternativeAuthor이하나-
dc.contributor.AlternativeAuthor전계선-
dc.contributor.AlternativeAuthor김동운-
dc.contributor.AlternativeAuthor조익현-
dc.contributor.AlternativeAuthor조사선-
dc.identifier.doi10.1007/s11064-009-0036-3-
dc.citation.journaltitleNEUROCHEMICAL RESEARCH-
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College of Medicine/School of Medicine (의과대학/대학원)Anatomy (해부학전공)Journal Papers (저널논문_해부학전공)
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