Publications
Detailed Information
Foxp3 Expression in p53-dependent DNA Damage Responses
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Jung, Da-Jung | - |
dc.contributor.author | Jin, Dong-Hoon | - |
dc.contributor.author | Hong, Seung-Woo | - |
dc.contributor.author | Kim, Jee-Eun | - |
dc.contributor.author | Kim, DaeJin | - |
dc.contributor.author | Hwang, Young-Il | - |
dc.contributor.author | Lee, Wang-Jae | - |
dc.contributor.author | Kang, Jae-Seung | - |
dc.contributor.author | Cho, Byung-Joo | - |
dc.contributor.author | Shin, Jae-Sik | - |
dc.date.accessioned | 2012-07-10T01:44:03Z | - |
dc.date.available | 2012-07-10T01:44:03Z | - |
dc.date.issued | 2010-03-12 | - |
dc.identifier.citation | JOURNAL OF BIOLOGICAL CHEMISTRY; Vol.285, No.11; 7995-8002 | ko_KR |
dc.identifier.issn | 0021-9258 | - |
dc.identifier.uri | https://hdl.handle.net/10371/78684 | - |
dc.description.abstract | The forkhead transcription factor, Foxp3, is thought to act as a master regulator that controls (suppresses) expression of the breast cancer oncogenes, SKP2 and HER-2/ErbB2. However, the mechanisms that regulate Foxp3 expression and thereby modulate tumor development remain largely unexplored. Here, we demonstrate that Foxp3 up-regulation requires p53 function, showing that Foxp3 expression is directly regulated by p53 upon DNA damage responses in human breast and colon carcinoma cells. Treatment with the genotoxic agents, doxorubicin or etoposide, induced Foxp3 expression in p53-positive carcinoma cells, but not in cells lacking p53 function. Furthermore, knock down of endogenous wild-type p53 using RNA interference abrogated Foxp3 induction by genotoxic agents, and exogenous expression of p53 in cells lacking p53 restored the responsiveness of Foxp3 to DNA-damaging stresses. In addition, Foxp3 knock down blunted the p53-mediated growth inhibitory response to DNA-damaging agents. These results suggest that induction of Foxp3 in the context of tumor suppression is regulated in a p53-dependent manner and implicate Foxp3 as a key determinant of cell fate in p53-dependent DNA damage responses. | ko_KR |
dc.description.sponsorship | This work was supported by the Korean Science and Engineering Foundation
through the Tumor Immunity Medical Research Center at Seoul National University College of Medicine Grant R13-2002-025-02001-0 and Science Research Center Program through the Research Center for Womens Diseases Grant R11-2005-017-03001. | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC | ko_KR |
dc.title | Foxp3 Expression in p53-dependent DNA Damage Responses | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 정다정 | - |
dc.contributor.AlternativeAuthor | 진동훈 | - |
dc.contributor.AlternativeAuthor | 홍승우 | - |
dc.contributor.AlternativeAuthor | 김지은 | - |
dc.contributor.AlternativeAuthor | 신재식 | - |
dc.contributor.AlternativeAuthor | 김대진 | - |
dc.contributor.AlternativeAuthor | 조병주 | - |
dc.contributor.AlternativeAuthor | 황영일 | - |
dc.contributor.AlternativeAuthor | 강재승 | - |
dc.contributor.AlternativeAuthor | 이왕재 | - |
dc.identifier.doi | 10.1074/jbc.M109.047985 | - |
dc.citation.journaltitle | JOURNAL OF BIOLOGICAL CHEMISTRY | - |
dc.description.citedreference | Ou-Yang HF, 2009, MOL CELL BIOCHEM, V320, P109, DOI 10.1007/s11010-008-9912-4 | - |
dc.description.citedreference | Ito T, 2008, IMMUNITY, V28, P870, DOI 10.1016/j.immuni.2008.03.018 | - |
dc.description.citedreference | Karanikas V, 2008, J TRANSL MED, V6, DOI 10.1186/1479-5876-6-19 | - |
dc.description.citedreference | Zuo T, 2007, J CLIN INVEST, V117, P3765, DOI 10.1172/JCI32538 | - |
dc.description.citedreference | Liu Y, 2007, PHARMACOGENOMICS, V8, P1485, DOI 10.2217/14622416.8.11.1485 | - |
dc.description.citedreference | Hinz S, 2007, CANCER RES, V67, P8344 | - |
dc.description.citedreference | Kinyamu HK, 2007, MOL CELL BIOL, V27, P4891, DOI 10.1128/MCB.02162-06 | - |
dc.description.citedreference | Zuo T, 2007, CELL, V129, P1275, DOI 10.1016/j.cell.2007.04.034 | - |
dc.description.citedreference | Liston A, 2007, CURR OPIN IMMUNOL, V19, P176, DOI 10.1016/j.coi.2007.02.005 | - |
dc.description.citedreference | Provinciali M, 2007, CANCER RES, V67, P2022, DOI 10.1158/0008-5472.CAN-06-2601 | - |
dc.description.citedreference | Traub F, 2006, BREAST CANCER RES TR, V99, P185, DOI 10.1007/s10549-006-9202-3 | - |
dc.description.citedreference | Kojima K, 2006, BLOOD, V108, P993, DOI 10.1182/blood-2005-12-5148 | - |
dc.description.citedreference | Wu YQ, 2006, CELL, V126, P375, DOI 10.1016/j.cell.2006.05.042 | - |
dc.description.citedreference | Mantel PY, 2006, J IMMUNOL, V176, P3593 | - |
dc.description.citedreference | Harris SL, 2005, ONCOGENE, V24, P2899 | - |
dc.description.citedreference | Fontenot JD, 2005, IMMUNITY, V22, P329, DOI 10.1016/j.immuni.2005.01.016 | - |
dc.description.citedreference | Choi BM, 2005, BIOCHEM BIOPH RES CO, V327, P1066, DOI 10.1016/j.bbrc.2004.12.106 | - |
dc.description.citedreference | Gondek DC, 2005, J IMMUNOL, V174, P1783 | - |
dc.description.citedreference | Nagaoka H, 2005, P NATL ACAD SCI USA, V102, P2022 | - |
dc.description.citedreference | Taams LS, 2005, CURR TOP MICROBIOL, V293, P115 | - |
dc.description.citedreference | Thompson T, 2004, J BIOL CHEM, V279, P53015, DOI 10.1074/jbc.M410233200 | - |
dc.description.citedreference | Jung MS, 2004, J BIOL CHEM, V279, P17765, DOI 10.1074/jbc.M305015200 | - |
dc.description.citedreference | Fontenot JD, 2003, NAT IMMUNOL, V4, P330, DOI 10.1038/ni904 | - |
dc.description.citedreference | Grohmann U, 2002, NAT IMMUNOL, V3, P1097, DOI 10.1038/ni846 | - |
dc.description.citedreference | Manzotti CN, 2002, EUR J IMMUNOL, V32, P2888 | - |
dc.description.citedreference | Vousden KH, 2002, NAT REV CANCER, V2, P594, DOI 10.1038/nrc864 | - |
dc.description.citedreference | Park WS, 2000, GASTROENTEROLOGY, V119, P691 | - |
dc.description.citedreference | Thornton AM, 1998, J EXP MED, V188, P287 | - |
dc.description.citedreference | Hermeking H, 1997, MOL CELL, V1, P3 | - |
dc.description.citedreference | MCILWRATH AJ, 1994, CANCER RES, V54, P3718 | - |
dc.description.citedreference | ELDEIRY WS, 1993, CELL, V75, P817 | - |
dc.description.citedreference | LOWE SW, 1993, CELL, V74, P957 | - |
dc.description.citedreference | HOLLSTEIN M, 1991, SCIENCE, V253, P49 | - |
dc.description.tc | 8 | - |
- Appears in Collections:
- Files in This Item:
- There are no files associated with this item.
Item View & Download Count
Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.