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Region-specific changes in the immunoreactivity of vasoactive intestinal peptide and pituitary adenylate cyclase-activating polypeptide receptors (VPAC(2), and PAC(1) receptor) in the aged rat brains

Cited 17 time in Web of Science Cited 17 time in Scopus
Authors
Lee, Jae Chul; Cho, Yu Jin; Kim, Jandi; Kim, Nahee; Cha, Choong Ik; Joo, Kyeung Min; Kang, Bong Gu
Issue Date
2010-09-10
Publisher
ELSEVIER SCIENCE BV
Citation
BRAIN RESEARCH; Vol.1351; 32-40
Keywords
VPAC(2) receptorImmunohistochemistryPAC(1) receptorAged rat brainExpressional change
Abstract
Pituitary adenylate cyclase-activating peptide (PACAP) and vasoactive intestinal peptide (VIP) have been implicated in a large array of physiological and patho-physiological processes through their receptors (VPAC(1), VPAC(2), and PAC(1) receptor) in the central nervous system. Previously, we demonstrated age-related decreases in VPAC(1) receptor expression in the rat brain providing a possible basis of several age-induced functional changes in the aged brain. In the current study, we also examined age-related changes in PAC(1) and VPAC(2) receptors in aged rat brains using an immunohistochemical approach. We found that PAC(1) immunoreactivity was significantly increased in the hippocampal formation, hypothalamus, thalamus, midbrain septal nuclei, and white matter of aged rats compared with young control rats although its distribution pattern was not altered. In contrast, both distribution pattern and immunoreactivity of VPAC(2) receptor remained unchanged in aged rat brains. These results suggest that the PACAP/VIP receptors exhibit specific expressional changes in the aged brain and that these specific changes could underlie age-associated memory and cognitive functional declines as well as several other age-induced functional changes in the brain. However, the exact regulatory mechanism and its functional significance require further elucidation.
ISSN
0006-8993
Language
English
URI
http://hdl.handle.net/10371/78694
DOI
https://doi.org/10.1016/j.brainres.2010.06.048
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College of Medicine/School of Medicine (의과대학/대학원)Anatomy (해부학전공)Journal Papers (저널논문_해부학전공)
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