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Changes in Glial Fibrillary Acidic Protein Immunoreactivity in the Dentate Gyrus and Hippocampus Proper of Adult and Aged Dogs

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dc.contributor.authorHwang, In Koo-
dc.contributor.authorChoi, Jung Hoon-
dc.contributor.authorLi, Hua-
dc.contributor.authorYoo, Ki-Yeon-
dc.contributor.authorKim, Dae Won-
dc.contributor.authorLee, Choong Hyun-
dc.contributor.authorYi, Sun Shin-
dc.contributor.authorSung, Je Kyeong-
dc.contributor.authorLee, In Se-
dc.contributor.authorYoon, Yeo Sung-
dc.contributor.authorWon, Moo-Ho-
dc.date.accessioned2009-08-27-
dc.date.available2009-08-27-
dc.date.issued2008-
dc.identifier.citationJ. Vet. Med. Sci. 70: 965-969en
dc.identifier.issn0916-7250 (print)-
dc.identifier.issn1347-7439 (online)-
dc.identifier.urihttp://hdl.handle.net/10371/7904-
dc.description.abstractAstrocytes perform neuron-supportive tasks, repair and scarring process in the central nervous system. In this study, we
observed glial fibrillary acidic protein (GFAP), a marker for astrocytes, immunoreactivity in the dentate gyrus and hippocampus proper
(CA1–3 region) of adult (2–3 years of age) and aged (10–12 years of age) dogs. In the adult group, GFAP immunoreactive astrocytes
were distributed in all layers of the dentate gyrus and CA1–3 region, except in the stratum pyramidale of the CA1–3 region. In the aged
group, GFAP immunoreactivity decreased markedly in the molecular layer of the dentate gyrus. However, GFAP immunoreactivity in
the CA1–3 region increased in all layers, and the cytoplasm of GFAP immunoreactive astrocytes was hypertrophied. GFAP protein levels
in the aged dentate gyrus decreased; however, GFAP levels in the CA1–3 region increased. These results suggest that the morphology
of astrocytes and GFAP protein levels in the hippocampal dentate gyrus and CA1 region are changed, respectively, with age.
en
dc.description.sponsorshipThe authors would like to
thank Mr. Seung Uk Lee and Ms. Hyun Sook Kim for their
technical help in this study. This work was supported by the
Korea Research Foundation Grant funded by the Korean
Government (MOEHRD) (KRF-2007–313-E00048).
en
dc.language.isoenen
dc.publisherJapanese Society of Veterinary Scienceen
dc.subjectagingen
dc.subjectastrocyteen
dc.subjectcanineen
dc.subjectglial fibrillary acidic proteinen
dc.subjecthippocampusen
dc.titleChanges in Glial Fibrillary Acidic Protein Immunoreactivity in the Dentate Gyrus and Hippocampus Proper of Adult and Aged Dogsen
dc.typeArticleen
dc.contributor.AlternativeAuthor황인구-
dc.contributor.AlternativeAuthor최정훈-
dc.contributor.AlternativeAuthor이화-
dc.contributor.AlternativeAuthor유기연-
dc.contributor.AlternativeAuthor김대원-
dc.contributor.AlternativeAuthor이충현-
dc.contributor.AlternativeAuthor이순신-
dc.contributor.AlternativeAuthor성제경-
dc.contributor.AlternativeAuthor이인세-
dc.contributor.AlternativeAuthor윤여성-
dc.contributor.AlternativeAuthor원무호-
dc.identifier.doi10.1292/jvms.70.965-
Appears in Collections:
College of Veterinary Medicine (수의과대학)Dept. of Veterinary Medicine (수의학과)Journal Papers (저널논문_수의학과)
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