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Generation of dynamic temporal and spatial concentration gradients using microfluidic devices

Cited 155 time in Web of Science Cited 159 time in Scopus
Authors
Lin, Francis; Saadi, Wajeeh; Rhee, Seog Woo; Wang, Shur-Jen; Mittal, Sukant; Jeon, Noo Li
Issue Date
2004-06
Publisher
Royal Society of Chemistry
Citation
Lab Chip, 2004, 4, 164-167
Keywords
gradientmicrofluidic device
Abstract
This paper describes a microfluidic approach to generate dynamic temporal and spatial concentration gradients using a single microfluidic device. Compared to a previously described method that produced a single fixed gradient shape for each device, this approach combines a simple mixer module with gradient generating network to control and manipulate a number of different gradient shapes. The gradient profile is determined by the configuration of fluidic inputs as well as the design of microchannel network. By controlling the relative flow rates of the fluidic inputs using separate syringe pumps, the resulting composition of the inlets that feed the gradient generator can be dynamically controlled to generate temporal and spatial gradients. To demonstrate the concept and illustrate this approach, examples of devices that generate (1) temporal gradients of homogeneous concentrations, (2) linear gradients with dynamically controlled slope, baseline, and direction, and (3) nonlinear gradients with controlled nonlinearity are shown and their limitations are described.
ISSN
1473-0197
Language
English
URI
http://hdl.handle.net/10371/7977
DOI
https://doi.org/10.1039/b313600k
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College of Engineering/Engineering Practice School (공과대학/대학원)Dept. of Mechanical Aerospace Engineering (기계항공공학부)Journal Papers (저널논문_기계항공공학부)
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