급성 일산화탄소중독시 고압산소요법시행이 백서의 임신손모에 미치는 영향

Abstract

There have been not a few clinical and experimental reports on the effect of acute carbon monoxide poisoning upon the course and outcome of pregnancy. Significantly high pregnancy wastage was observed and the interruption of pregnancy was found to be typical pattern of wastage. The hypoxic effect by the formation of fetal carboxyhemoglobin is regarded as main cause of the wastage. Author designed this study to confirm the effect of hyperbaric oxygenation on the pregnancy wastage followed by acute carbon monoxide poisoning. Using albino rats, experimental groups were divided into control, acute exposure and no treatment, acute exposure and hyperbaric oxygenation, and hyperbaric oxygenation without exposure. Exposed groups were exposed to the concentration of 5,000 ppm of carbon monoxide for 20 minutes. Following findings were observed as the experimental results; 1. The pregnancy wastage was prominent at the stage corresponding to the organogenesis. As a result, total interruption rate was the highest during the 8th to 11th embryonic day. 2. The treatment measures with the hyperbaric oxygenation followed by acute carbon monoxide poisoning ensued in remarkable reduction of pregancy wastage. This finding is indicating the alleviation of hypoxic effect of carbon monoxide poisoning by hyperbaric oxygenation and neutralization of the adverse effect of hypoxia in inducing pregnancy wastage. 3. Hyperbaric oxygenation per se represents no particular hazard to the pregnancy. 4. There have been no changes in fctal body weight among experimental groups that sustained the pregnancy to term. Hemogram at term also showed no significant changes. These findings make such speculation possible that the hypoxic effect induced by acute carbon monoxide wouldn't persist longer since the cessation of carbon monoxide exposure.