S-Space College of Medicine/School of Medicine (의과대학/대학원) Dept. of Medicine (의학과) The Seoul Journal of Medicine The Seoul Journal of Medicine Vol. 23 No.2 (1982)
임신과 수유기간 중 생쥐 임파기관 내의 형질세포에 관한 연구 1. 흉선에서의 관찰
Studies on the Plasma Cells in the Lymphoid Organ during Pregnancy and Lactation in the Mouse I. Observations in the Thymus
- 장가용; 황덕호; 이광호; 차중익
- Issue Date
- 서울대학교 의과대학
- Seoul J Med, Vol.23 No.2, pp. 165-172
- The following experiment was performed to study
on the numerical changes of the IgG, IgM and IgA
bearing cells in the thymus during pregnancy and
lactation in the mouse. The experimental animals
were mated allogeneically (female ICRC x male
DDY), and the thymi were resected at 4, 6 and 19
days of gestation and postpartum 20 days. The thymi
were stained with MGP and immunohistochemical
reaction. Then each group was compared with the
virgin control group.
The following results were obtained:
1. In 6 days of gestation, the number of IgA bearing
cells was significantly more than that in virgin.
2. In 19 days of gestation, the number of IgG. IgM
and IgA bearing cells was significantly more
than that in virgin.
3. In suckling group, the number of IgG and IgA
bearing cells was significantly more than that
4. The immunoglobulin bearing cells were localized
in perivascular region.
On the basis of the above results, it is suggested
that the thymus. the primary lymphoid organ, has
relation with the maternal immune response, too.