SHERP

기관지천식환자에 있어서의 Cyclic Nucleotide의 혈장농도에 관한 연구
A Study of the Plasma Level of Cyclic Nucleotides in Bronchial Asthmatics

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Authors
강석영; 김유영; 최병휘; 박춘식
Issue Date
1982-06
Publisher
서울대학교 의과대학
Citation
Seoul J Med 1982;23(2):196-200
Abstract
The plasma levels of cyclic adenosine 3',5'-monophosphate
(cAMP) and cyclic guanosine 3',5'-mono
phosphate (cGMP) and the serum level of aminophylline
were measured in bronchial asthmatics. Their
ages ranged from 5 years to 89 years and durations
of symptom from 3 months to 30 years. Blood
samplings were taken between 10:00 AM and 12:00
MD.
1. In bronchia! asthmatics, the mean plasma level
of cAMP was 9. 7±7. 1 pmol/ml(mean±S.D., l pmol/
ml to 38pmol/ml) and was significantly higher than
that of norma! adults (p<O.01). The mean plasma level of cGMP was 3. 9±1. 7 pmol/ml (mean±S.D.,
0.5 pmol/ml to 9.2 pmol/ml) and was not significantly
different from normal adults.
2. In bronchial asthmatics without wheezing whose
serum levels of aminophylline were not detected, the
mean plasma levels of cAMP and cGMP were 8.9±
7.8 pmol/ml and 3. 7±2. 0 pmol/ml respectively. In
bronchial asthmatics with wheezing whose serum
levels of aminophylline were not detected, the mean
plasma levels of cAMP and cGMP were 7. 7±5. 7
pmol/ml and 4.4::1.2.0 prnol/rnl (mean ±S.D.) respectively.
There was no significant difference between
bronchial asthmatics with wheezing and those without
wheezing.
3. In bronchial asthmatics whose serum levels of
aminophylline were higher than 2.5pg/ml, the mean
plasma level of cAMP was significantly higher than
bronchial asthmatics whose serum levels of aminophylline
were not detected (p<O.OI). But the mean
plasma level of cGMP was not different significa·
ntly (p>0.05).
4. There was no correlation between the serum
level of aminophylline and the plasma levels of cAMP
and cGMP.
Language
Korean
URI
http://hdl.handle.net/10371/8033
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Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Dept. of Medicine (의학과)The Seoul Journal of MedicineThe Seoul Journal of Medicine Vol. 23 No.2 (1982)
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