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Effects of HA released calcium ion on osteoblast differentiation
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Jung, Gil-Yong | - |
dc.contributor.author | Park, Yoon-Jeong | - |
dc.contributor.author | Han, Jung-Suk | - |
dc.date.accessioned | 2013-01-14T05:58:19Z | - |
dc.date.available | 2013-01-14T05:58:19Z | - |
dc.date.issued | 2010-05 | - |
dc.identifier.citation | JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE, Vol.21, No.5, pp.1649-1654 | ko_KR |
dc.identifier.issn | 0957-4530 | - |
dc.identifier.uri | https://hdl.handle.net/10371/80378 | - |
dc.description.abstract | Hydroxyapatite (HA) is a widely used calcium phosphate implant substitute and has dissolution property. Although HA has been shown a beneficial effect on osteoblast differentiation, the exact mechanism is still unclear. In the present study, we proposed that Ca(2+) released from HA activated the expression bone associated proteins, OPN and BSP, mediated by L-type calcium channel and calcium/calmodulin-dependent protein kinase (CaMK) 2 which resulted into improved osteoblast differentiation. Results showed that HA elevated ALP expression as well as OPN and BSP expression in MC3T3-E1 cells. The result from western blot of CaMK2 alpha indicated that HA released Ca(2+) activated CaMK2 through L-type calcium channel. Furthermore, upregulation of OPN and BSP mRNA expression was significantly inhibited when blocking both the L-type calcium channel and CaMK2. These findings suggested that HA accelerated the osteoblast differentiation by releasing Ca(2+). | ko_KR |
dc.description.sponsorship | This study was supported by the grant of Korea
Science and Engineering Foundation (KOSEF) grant funded by the Korea government (MOST) No. R01-2007-000-10977-0 and Ministry of Science and Technology (Regenomics, M10528010004-06N2801-00410). | - |
dc.language.iso | en | ko_KR |
dc.publisher | SPRINGER | ko_KR |
dc.title | Effects of HA released calcium ion on osteoblast differentiation | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 정길용 | - |
dc.contributor.AlternativeAuthor | 박윤정 | - |
dc.contributor.AlternativeAuthor | 한중석 | - |
dc.identifier.doi | 10.1007/s10856-010-4011-y | - |
dc.citation.journaltitle | JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE | - |
dc.description.tc | 8 | - |
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