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Microglial Toll-like Receptor 2 Contributes to Kainic Acid-induced Glial Activation and Hippocampal Neuronal Cell Death
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Hong, Jinpyo | - |
dc.contributor.author | Cho, Ik-Hyun | - |
dc.contributor.author | Kwak, Kyung Il | - |
dc.contributor.author | Suh, Eun Cheng | - |
dc.contributor.author | Min, Hyun Jung | - |
dc.contributor.author | Kim, Chong-Hyun | - |
dc.contributor.author | Jo, Eun-Kyeong | - |
dc.contributor.author | Lee, Kyung Eun | - |
dc.contributor.author | Lee, Sung Joong | - |
dc.contributor.author | Lee, Soojin | - |
dc.contributor.author | Park, Seung Hwa | - |
dc.contributor.author | Choi, Se-Young | - |
dc.contributor.author | Seo, Jinsoo | - |
dc.date.accessioned | 2013-01-14T06:07:31Z | - |
dc.date.available | 2013-01-14T06:07:31Z | - |
dc.date.issued | 2010-12 | - |
dc.identifier.citation | JOURNAL OF BIOLOGICAL CHEMISTRY, Vol.285, No.50, pp.39447-39457 | ko_KR |
dc.identifier.issn | 0021-9258 | - |
dc.identifier.uri | https://hdl.handle.net/10371/80391 | - |
dc.description.abstract | Recent studies indicate that Toll-like receptors (TLRs), originally identified as infectious agent receptors, also mediate sterile inflammatory responses during tissue damage. In this study, we investigated the role of TLR2 in excitotoxic hippocampal cell death using TLR2 knock-out (KO) mice. TLR2 expression was up-regulated in microglia in the ipsilateral hippocampus of kainic acid (KA)-injected mice. KA-mediated hippocampal cell death was significantly reduced in TLR2 KO mice compared with wild-type (WT) mice. Similarly, KA-induced glial activation and proinflammatory gene expression in the hippocampus were compromised in TLR2 KO mice. In addition, neurons in organotypic hippocampal slice cultures (OHSCs) from TLR2 KO mouse brains were less susceptible to KA excitotoxicity than WT OHSCs. This protection is partly attributed to decreased expression of proinflammatory genes, such as TNF-alpha and IL-1 beta in TLR2 KO mice OHSCs. These data demonstrate conclusively that TLR2 signaling in microglia contributes to KA-mediated innate immune responses and hippocampal excitotoxicity. | ko_KR |
dc.description.sponsorship | This work was supported by the National Research Foundation of Korea, funded by the Ministry of Education, Science and Technology (MEST) (No. 2009-0081467, 2009-0063285, 2009-0053167), the Republic of Korea, and the Korea Science and Engineering Foundation through the Infection Signaling Network Research Center (R13-2007-020-01000-0) at Chungnam National University. | - |
dc.language.iso | en | ko_KR |
dc.publisher | AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC | ko_KR |
dc.title | Microglial Toll-like Receptor 2 Contributes to Kainic Acid-induced Glial Activation and Hippocampal Neuronal Cell Death | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 홍진표 | - |
dc.contributor.AlternativeAuthor | 조익현 | - |
dc.contributor.AlternativeAuthor | 곽경일 | - |
dc.contributor.AlternativeAuthor | 서은정 | - |
dc.contributor.AlternativeAuthor | 민현정 | - |
dc.contributor.AlternativeAuthor | 김종현 | - |
dc.contributor.AlternativeAuthor | 조은경 | - |
dc.contributor.AlternativeAuthor | 이경은 | - |
dc.contributor.AlternativeAuthor | 이성중 | - |
dc.contributor.AlternativeAuthor | 이수진 | - |
dc.contributor.AlternativeAuthor | 박성화 | - |
dc.contributor.AlternativeAuthor | 최세영 | - |
dc.contributor.AlternativeAuthor | 서진수 | - |
dc.identifier.doi | 10.1074/jbc.M110.132522 | - |
dc.citation.journaltitle | JOURNAL OF BIOLOGICAL CHEMISTRY | - |
dc.description.tc | 4 | - |
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