이질균의 항균제 내성과 균간전달

Abstract

Pattern and transferability of antimicrobial resistance were investigated in 114 Shigella isolates from diarrheal patients at two large general hospitals in Seoul, Korea. Resistance to 6 antimicrobial drugs which have been widely used in Korea was widespread; ampicillin (83.396), tetracycline (94.796), chloramphenicol (96.596), streptomycin (10096), sulfamerazine (94. 7 96), co·trimoxazole(88. 496). Only one strain was susceptible to any of the above 6 drugs and the remaining strains (9996) were resistant to more than one of the above 6 drugs. Among the various kinds of the multiple resistance. the most predominant pattern was sextuple resistance to all of the above 6 drugs (80.796 of all the isolates) . Majority (8996) of the various kinds of multiple resistance to the 6 drugs was demonstrated transferable to E. coli, indicating that transferable R plasmids are operating the most important mechanism in the emergence of antimicrobial resistance in Shigella in Korea. Resistance to gentamicin (9.6%), rifampicin (5.8 96), oxolinic acid (7.096), cefoperazone (4.496) which have not been available in a nationwide aspect of Korea was not common. From the distributions of MIC's to 12 antimicrobial drugs, it is suggested that resistance to kanamycin and nalidixic acid is emerging in the Shigella.