이질균의 항균제 내성과 균간전달
Antimicrobial Resistance of Shigella and its Transferability

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이광호; 차창룡; 석종성
Issue Date
서울대학교 의과대학
Seoul J Med 1982;23(3):292-298
Pattern and transferability of antimicrobial resistance
were investigated in 114 Shigella isolates from
diarrheal patients at two large general hospitals in
Seoul, Korea.
Resistance to 6 antimicrobial drugs which have
been widely used in Korea was widespread; ampicillin
(83.396), tetracycline (94.796), chloramphenicol
(96.596), streptomycin (10096), sulfamerazine (94. 7
96), co·trimoxazole(88. 496).
Only one strain was susceptible to any of the above
6 drugs and the remaining strains (9996) were resistant
to more than one of the above 6 drugs.
Among the various kinds of the multiple resistance.
the most predominant pattern was sextuple resistance
to all of the above 6 drugs (80.796 of all the
isolates) .
Majority (8996) of the various kinds of multiple
resistance to the 6 drugs was demonstrated transferable
to E. coli, indicating that transferable R plasmids
are operating the most important mechanism in
the emergence of antimicrobial resistance in Shigella
in Korea.
Resistance to gentamicin (9.6%), rifampicin (5.8
96), oxolinic acid (7.096), cefoperazone (4.496)
which have not been available in a nationwide aspect
of Korea was not common.
From the distributions of MIC's to 12 antimicrobial
drugs, it is suggested that resistance to kanamycin
and nalidixic acid is emerging in the Shigella.
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College of Medicine/School of Medicine (의과대학/대학원)Dept. of Medicine (의학과)The Seoul Journal of MedicineThe Seoul Journal of Medicine Vol. 23 No.3 (1982)
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