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Effect of acidic degradation products of poly(lactic-co-glycolic)acid on the apatite-forming ability of poly(lactic-co-glycolic)acid-siloxane nanohybrid material

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Authors
Rhee, Sang-Hoon; Lee, Seung Jin
Issue Date
2007-12-01
Publisher
WILEY-LISS
Citation
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A, Vol.83A, No.3, pp.799-805
Keywords
poly(lactic-co-glycolic acid)aciditydissolutiondegradation productapatite
Abstract
The effect of poly(lactic-co-glycolic) acid (PLGA) degradation products on the apatite-forming ability of a PLGA-siloxane nanohybrid material were investigated. Two PLGA copolymer compositions with low and high degradability were used in the experiment. The PLGA-siloxane nanohybrid materials were synthesized by end-capping PLGA with acid end-groups using 3-isocyanatopropyl triethoxysilane following the sol-gel reaction with calcium nitrate tetrahydrate. Two nanohybrid materials that had different degradability were exposed to simulated body fluid (SBF) for 1-28 days at 36.5 degrees C. The low degradable PLGA hybrid showed apatite-forming ability within 3 days of incubation while the high degradable one did not within 28 days testing period. The results were explained in terms of the acidity of the PLGA degradation products, which could directly influence on the apatite dissolution. (C) 2007 Wiley Periodicals, Inc.
ISSN
1549-3296
Language
English
URI
http://hdl.handle.net/10371/80468
DOI
https://doi.org/10.1002/jbm.a.31405
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College of Dentistry/School of Dentistry (치과대학/치의학대학원)Dept. of Dentistry (치의학과)Journal Papers (저널논문_치의학과)
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