Chlorpromazine과 Bromocriptine이 흰쥐 뇌하수체 Prolactin 세포에 미치는 영향에 관한 실험적 연구
Experimental Study of Pituitary Prolactin Cells on the Effect of Chlorpromazine and Bromocriptine Administration in Rats

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황석남; 최길수; 함의근; 조사선
Issue Date
서울대학교 의과대학
Seoul J Med 1982;23(3):310-322
Hypcrprolactincmia which is produced by pituitary
tumor, lesions involving hypothalamo-hypophyscal
tract and various drugs has important medical
significance because of its close relationship with
Among various drugs which produce hyperprolactincrnia
chlorpromazine rapidly elevates blood level of
prolactin by blocking the PIF receptor of the pituitary
prolactin cells.
Bromocriptine is a semisynthetic tripeptide ergot
alkaloid and it has high specificity to the prolactin
cells. It rapidly lowers blood prolactin level by stimulating
the PIF receptor of the prolactin cells at
the pituitary level and a few other mechanisms.
Furthermore bromocriptine is known to inhibit
growth hormone cells directly though still in a controversy.
Chlorpromazine and bromocriptine were administered
to 120 male rats grouped into 5. Pituitary,
adrenals and testes were weighed. Pituitary was prepared
for ligh t microscopic, electron microscopic and
enzyme cytochemical study. By light microscope, the
numbers of the acidophils were counted and sizes
were measured for statistical analysis and by electron
microscope the ultrastructural changes of the prolactin
and growth hormone cells were examined.
The results were as follows.
1. By light microscope there was no significant
change in numbers of acidophils between each
group but there was significant decrease in size of
acidophils of combined chlorpromazine and bromocriptine
group compared with control and chlorpromazine
2. By electron microscope there were severe depletion
of prolactin granules and marked development of
endoplasmic reticulum and Golgi complex in chlorpromazine
group. In combined chlorpromazine and
bromocriptine group, there was no significant change
of prolactin granules but cellular organelles
were markedly decreased in number. With continued
bromocriptine administration, cell border and
nuclear membrane of the prolactin cell became indistinct
and most of the prolactin cells were atrophied
with pyknotic nuclei. Growth hormone cells
showed no significant changes in each group corn-
pared with control group.
3. Enzyme staining of the anterior pituitary showed
decreased' activities of NADH and TPPase in
chlorpromazine group and combined chlorpromazine
and bromocriptine group.
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College of Medicine/School of Medicine (의과대학/대학원)Dept. of Medicine (의학과)The Seoul Journal of MedicineThe Seoul Journal of Medicine Vol. 23 No.3 (1982)
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