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Differential inhibition of transmembrane 4 L six family member 5 (TM4SF5)-mediated tumorigenesis by TSAHC and sorafenib
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Sin-Ae | - |
dc.contributor.author | Lee, Mi-Sook | - |
dc.contributor.author | Ryu, Hyung Won | - |
dc.contributor.author | Kwak, Tae Kyoung | - |
dc.contributor.author | Kang, Minkyung | - |
dc.contributor.author | Kim, Hyun Jeong | - |
dc.contributor.author | Lee, Jung Weon | - |
dc.contributor.author | Park, Ki Hun | - |
dc.contributor.author | Jung, Oisun | - |
dc.contributor.author | Kim, Hyeonjung | - |
dc.date.accessioned | 2013-01-15T00:30:52Z | - |
dc.date.available | 2013-01-15T00:30:52Z | - |
dc.date.issued | 2011-02-01 | - |
dc.identifier.citation | CANCER BIOLOGY & THERAPY, Vol.11, No.3, pp.330-336 | ko_KR |
dc.identifier.issn | 1538-4047 | - |
dc.identifier.uri | https://hdl.handle.net/10371/80534 | - |
dc.description.abstract | Two separate clinical studies of advanced hepatocarcinoma patients recently reported that the multikinase inhibitor sorafenib (nexavar) could extend survival of the patients only by 2-3 months. We also previously demonstrated that 4`-(p-toluenesulfonylamido)-4-hydroxychalcone (TSAHC) blocks the multilayer growth and migration mediated by TM4SF5, which is highly expressed in approximately 80% of Korean hepatocarcinoma patients. Therefore, we wondered how TSAHC might be different from sorafenib to deal with hepatocarcinoma in terms of the therapeutic characteristics including specificity for TM4SF5. TM4SF5 is previously shown to mediate tumorigenesis through cytosolic p27(Kip1)-mediated inactivation of RhoA, epithelial-mesenchymal transition, multilayer growth, migration, invasion and tumor angiogenesis. In this study, TSAHC and two derivatives showed similar antagonistic activities against TM4SF5-mediated signaling and multilayer growth in vitro and anti-tumorigenic activity even in early stages of TM4SF5-mediated tumor formation in nude mice. Meanwhile, sorafenib was only effective much later in tumorigenesis in vivo and affected in vitro proliferation in a TM4SF5-independent manner. Altogether, these observations suggest that TSAHC may be a promising anti-tumorigenic reagent, especially against TM4SF5-mediated hepatocarcinoma. | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | LANDES BIOSCIENCE | ko_KR |
dc.subject | contact inhibition | ko_KR |
dc.subject | TM4SF5 | ko_KR |
dc.subject | sorafenib | ko_KR |
dc.subject | liver carcinoma | ko_KR |
dc.subject | anti-tumorigenic reagent | ko_KR |
dc.title | Differential inhibition of transmembrane 4 L six family member 5 (TM4SF5)-mediated tumorigenesis by TSAHC and sorafenib | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 이신애 | - |
dc.contributor.AlternativeAuthor | 이미숙 | - |
dc.contributor.AlternativeAuthor | 류형원 | - |
dc.contributor.AlternativeAuthor | 곽태경 | - |
dc.contributor.AlternativeAuthor | 강민경 | - |
dc.contributor.AlternativeAuthor | 김현정 | - |
dc.contributor.AlternativeAuthor | 이정원 | - |
dc.contributor.AlternativeAuthor | 박기훈 | - |
dc.contributor.AlternativeAuthor | 정외선 | - |
dc.contributor.AlternativeAuthor | 김현정 | - |
dc.identifier.doi | 10.4161/cbt.11.3.14099 | - |
dc.citation.journaltitle | CANCER BIOLOGY & THERAPY | - |
dc.description.tc | 1 | - |
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