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Recurrent odontogenic ghost cell carcinoma (OGCC) at a reconstructed fibular flap: A case report with immunohistochemical findings

Cited 13 time in Web of Science Cited 16 time in Scopus
Authors

Li, Bo-Han; Cho, Young-Ah; Kim, Soung-Min; Kim, Myung-Jin; Lee, Jong-Ho; Hong, Sam-Pyo

Issue Date
2011-08
Publisher
Medicina Oral S.L.
Citation
MEDICINA ORAL PATOLOGIA ORAL Y CIRUGIA BUCAL, Vol.16, No.5, pp.E651-E656
Keywords
Odontogenic ghost cell carcinoma (OGCC)odontogenic ghost cell tumor (OGCT)immunohistochemical findingmalignant transformation
Abstract
Odontogenic ghost cell carcinoma (OGCC), a malignant counterpart of the odontogenic ghost cell tumor (OGCT), with aggressive growth characteristics, is exceedingly rare. A painful swelling in the jaw with local paresthesia is the most common symptom. We described a case of 47-year Korean woman who had a rare central epithelial odontogenic ghost cell carcinoma which recurred at reconstructed fibular flap. Immunohistochemical differences between OGCT and OGCC analyzed using primary and recurred surgical specimen. On the basis of this case, the tumor started as an OGCT and transformed into OGCC with highly aggressive, rapidly growing, infiltrative tumors. Our findings suggest that some of the cytokines produced by ghost cells may play important roles in causing extensive bone resorption in the odontogenic ghost cell carcinoma. Wide local excision with histologically clean margins is the treatment mode of selection. Also, we recommend close long-term surveillance of OGCT because of high recurrence and potential for malignancy transformation.
ISSN
1698-4447
Language
English
URI
https://hdl.handle.net/10371/80540
DOI
https://doi.org/10.4317/medoral.17207
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