녹농균증에 대한 다가 녹농균 백신효과의 실험적 연구
Experimental study on effect of polyvalent pseudomonas vaccine against pseudomonas infection

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장우현; 최명식; 이광호; 석종성
Issue Date
서울대학교 의과대학
Seoul J Med 1982;23(4):436-442
Pseudomonas aeruginosa is a well-known nosocomial
pathogen and chemotherapy of the pseudomonas
infection is limited due to the intrinsic resistance of
this organism to antimicrobial agents and to susceptibility
of compromised hosts to this infection.
To find out an effective immunological measure for
the prevention and control of the pseudomonas
infection, the frequency of Pseudomonas aeruginosa
serotypes prevalent in the SNUH environment was
surveyed and distribution of serological cross-reaction
was determined.
On the basis of the results obtained from the
serological cross reactions, the 10 representative
serotypes were divided into two polyvalent vaccines.
And protective effect of the polyvalent vaccine
were evaluated in the ICR mice.
Following results were obtained.
1. Serotypes of 64 strains of Pseudomonsa aeruginosa
isolated from SNUH ennvironment were as
follow: serotype C were 14 (21. 9%), serotype B
were 13(20.6%), serotype E were 10 OS. 696),
serotype G were 7 00.9%), serotype A were 6
(9.496), serotype F were 3 (4.7%), serotype D
were 2 (3.1%) and serotype 1 was 1 0.6%).
2. Heat killed whole cell polyvalent pseudomonas
vaccine has protective effect against the infection induced experimentally by 12 serotypes of Pseudomonas
3. Heat killed polyagglutinable pseudomonas vaccine
has protective effect against the infection
induced by only 7 serotypes of Pseudomonas aeruginosa
and protective effect and agglutinin titer were
not correlated.
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College of Medicine/School of Medicine (의과대학/대학원)Dept. of Medicine (의학과)The Seoul Journal of MedicineThe Seoul Journal of Medicine Vol. 23 No.4 (1982)
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