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Molecular Responses in Osteogenic Differentiation of Mesenchymal Stem Cells Induced by Physical Stimulation

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Authors
Togloom, Ariunaa; Lim, Ki-Taek; Kim, Jang-Ho; Seonwoo, Hoon; Choung, Pill-Hoon; Choung, Yun-Hoon; Chung, Jong Hoon; Cho, Chong-Su; Garg, Pankaj
Issue Date
2011-06
Publisher
KOREAN TISSUE ENGINEERING REGENERATIVE MEDICINE SOC
Citation
TISSUE ENGINEERING AND REGENERATIVE MEDICINE; Vol.8, No.3, pp.271-281
Keywords
physical stimulationmechanotransductionosteogenic differentiationgene expressionsignal transduction
Abstract
Mesenchymal stem cells (MSCs) have been recognized as a great source of stem cells in the field of regenerative medicine and regulation of MSCs such as differentiation into specific cells. Particular interest is the use of physical stimulation for the expression of the osteoblast-specific genes from MSCs for bone tissue regeneration. The mechanical forces on MSCs, such as fluid flow, enhance the mineralized matrix and specific gene expressions. This process called mechanotransduction comprises of the steps of mechanoreception, biochemical coupling, transmission of signal and effector cell response. Physical stimuli effectively regulate extracellular and intracellular signaling pathways to enhance the expression of specific transcription factors, and the release of osteocytes, ultimately expedite the production of active osteoblasts. Thus understating, identification and functional characterization of the mechanotransduction underlying the physical stimulation of MSCs is a critical issue for devising new bone regenerative treatments for bone-related diseases. In this review, we focus on the molecular mechanism responsible for the mechanotransduction of osteogenic differentiation of MSCs induced by physical stimulation.
ISSN
1738-2696
Language
English
URI
http://hdl.handle.net/10371/80839
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College of Dentistry/School of Dentistry (치과대학/치의학대학원)Dept. of Dentistry (치의학과)Journal Papers (저널논문_치의학과)
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