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Biological effects of a root conditioning agent for dentin surface modification in vitro

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dc.contributor.authorLee, Jue-Yeon-
dc.contributor.authorSeol, Yang-Jo-
dc.contributor.authorPark, Jang-Ryul-
dc.contributor.authorPark, Yoon-Jeong-
dc.contributor.authorChung, Chong-Pyoung-
dc.date.accessioned2013-01-21T07:35:31Z-
dc.date.available2013-01-21T07:35:31Z-
dc.date.issued2010-
dc.identifier.citationJournal of Periodontal and Implant Science; Vol.40, No.6, pp.257-264ko_KR
dc.identifier.issn2093-2278-
dc.identifier.urihttp://hdl.handle.net/10371/80883-
dc.description.abstractPurpose: Connective tissue reattachment to periodontally damaged root surfaces is one of the most important goals of periodontal therapy. The aim of this study was to develop a root conditioning agent that can demineralize and detoxify the infected root surface. Methods: Dentin slices obtained from human teeth were treated with a novel root planing agent for 2 minutes and then washed with phosphate-buffered saline. Smear layer removal and type I collagen exposure were observed by scanning electron microscopy (SEM) and type I collagen immunostaining, respectively. Cell attachment and lipopolysaccharides (LPS) removal demonstrated the efficiency of the root conditioning agent. Results: SEM revealed that the smear layer was entirely removed and the dentinal tubules were opened by the experimental gel. Type I collagen was exposed on the surfaces of the dentin slices treated by the experimental gel, which were compared with dentin treated with other root planing agents. Dentin slices treated with the experimental gel showed the highest number of attached fibroblasts and flattened cell morphology. The agar diffusion assay demonstrated that the experimental gel also has effective antimicrobial activity. Escherichia coli LPS were effectively removed from well plates by the experimental gel. Conclusions: These results demonstrated that this experimental gel is a useful tool for root conditioning of infected root surfaces and can also be applied for detoxification of ailing implant surface threads. ⓒ 2010 Korean Academy of Periodontology.ko_KR
dc.language.isoenko_KR
dc.publisherKorean Academy of Periodontologyko_KR
dc.subjectCell attachmentko_KR
dc.subjectSmear layerko_KR
dc.subjectLipopolysaccharideko_KR
dc.subjectCollagenko_KR
dc.subjectDemineralizationko_KR
dc.titleBiological effects of a root conditioning agent for dentin surface modification in vitroko_KR
dc.typeArticleko_KR
dc.contributor.AlternativeAuthor이주연-
dc.contributor.AlternativeAuthor설양조-
dc.contributor.AlternativeAuthor박장열-
dc.contributor.AlternativeAuthor박윤정-
dc.contributor.AlternativeAuthor정종평-
dc.identifier.doi10.5051/jpis.2010.40.6.257-
dc.citation.journaltitleJournal of Periodontal and Implant Science-
dc.description.tc1-
Appears in Collections:
College of Dentistry/School of Dentistry (치과대학/치의학대학원)Dept. of Dentistry (치의학과)Journal Papers (저널논문_치의학과)
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