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Expression profile of the stem cell markers in human hertwig`s epithelial root sheath/Epithelial rests of Malassez cells

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dc.contributor.authorNam H.-
dc.contributor.authorKim J.-
dc.contributor.authorPark J.-
dc.contributor.authorPark J.-C.-
dc.contributor.authorSeo B.-M.-
dc.contributor.authorLee G.-
dc.contributor.authorLee J.C.-
dc.contributor.authorKim J.-W.-
dc.date.accessioned2013-01-22T04:15:29Z-
dc.date.available2013-01-22T04:15:29Z-
dc.date.issued2011-
dc.identifier.citationMolecules and Cells, Vol.31, No.4, pp.355-360ko_KR
dc.identifier.issn1016-8478-
dc.identifier.urihttp://hdl.handle.net/10371/80942-
dc.description.abstractHertwig`s epithelial root sheath/Epithelial rests of Malassez (HERS/ERM) cells are unique epithelial cells in the periodontal ligament. They remain in periodontal tissues throughout the adult life, and it is expected that their functional role is to maintain the homeostasis of the periodontium through reciprocal interactions with other periodontal cells. In this study, we investigated whether HERS/ERM cells have primitive stem cell characteristics: those of embryonic stem cells as well as of epithelial stem cells. Primary HERS/ERM cells had typical epithelial cell morphology and characteristics and they maintained for more than five passages. They expressed epithelial stem cell-related genes: ABCG2, ?Np63, p75, EpCAM, and Bmi-1. Moreover, the expression of embryonic stem cell markers such as Oct-4, Nanog, and SSEA-4 were detected. Next, we investigated whether the expression of these stem cell markers was maintained during the sub-culture process. HERS/ERM cells showed different expression levels of these stemness genes at each passage, but their expression was maintained throughout the passages. Taken together, our data suggest that a primary culture of HERS/ERM cells contains a population of primitive stem cells that express epithelial stem cell markers and embryonic stem cell markers. Furthermore, these cell populations were maintained during the sub-culturing process in our culture conditions. Therefore, our findings suggest that there is a strong possibility of accomplishing cementum tissue engineering with HERS/ERM cells.ko_KR
dc.language.isoenko_KR
dc.publisherKorean Society for Molecular and Cellular Biologyko_KR
dc.subjectEmbryonic stem cellsko_KR
dc.subjectEpithelial stem cellsko_KR
dc.subjectHertwig`s epithelial root sheath/Epithelial rests of Malassez cellsko_KR
dc.subjectStem cell markersko_KR
dc.titleExpression profile of the stem cell markers in human hertwig`s epithelial root sheath/Epithelial rests of Malassez cellsko_KR
dc.typeArticleko_KR
dc.contributor.AlternativeAuthor남현-
dc.contributor.AlternativeAuthor김재원-
dc.contributor.AlternativeAuthor박재완-
dc.contributor.AlternativeAuthor박주철-
dc.contributor.AlternativeAuthor서병무-
dc.contributor.AlternativeAuthor이진-
dc.contributor.AlternativeAuthor이재천-
dc.contributor.AlternativeAuthor김정욱-
dc.identifier.doi10.1007/s10059-011-0045-3-
dc.citation.journaltitleMolecules and Cells-
dc.description.tc6-
Appears in Collections:
College of Dentistry/School of Dentistry (치과대학/치의학대학원)Dept. of Dentistry (치의학과)Journal Papers (저널논문_치의학과)
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