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Magnolia officinalis Reverses Alcoholic Fatty Liver by Inhibiting the Maturation of Sterol Regulatory Element-Binding Protein-1c

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dc.contributor.authorYin, Hu-Quan-
dc.contributor.authorJe, Young-Tae-
dc.contributor.authorKim, Young-Chul-
dc.contributor.authorShin, Young-Kee-
dc.contributor.authorLee, KiYong-
dc.contributor.authorKim, Youn-Chul-
dc.contributor.authorLee, Byung-Hoon-
dc.contributor.authorJeong, Gil-Saeng-
dc.contributor.authorSung, SangHyun-
dc.date.accessioned2013-01-22T05:23:40Z-
dc.date.available2013-01-22T05:23:40Z-
dc.date.issued2009-04-
dc.identifier.citationJOURNAL OF PHARMACOLOGICAL SCIENCES; Vol.109, No.4, pp.486-495ko_KR
dc.identifier.issn1347-8613-
dc.identifier.urihttp://hdl.handle.net/10371/80956-
dc.description.abstractThe generally accepted hypothesis for the pathogenesis of alcoholic liver disease (ALD) is the two-hit model, which proposes that fat accumulation in the liver increases the sensitivity of the liver to a second hit that leads to inflammatory liver cell damage. In this study we evaluated the effects of Magnolia officinalis (MO), which contains honokiol and magnolol as the primary pharmacological components, to eradicate fatty liver in rats fed an ethanol diet. In vitro Studies showed that MO was able to protect RAW 264.7 cells from ethanol-induced production of tumor necrosis factor-alpha, reactive oxygen species, and superoxide anion radicals; the activation of NADPH oxidase; and Subsequent cell death. We also investigated the therapeutic effects of MO on alcoholic fatty liver in Lieber-DeCarli ethanol diet-fed rats. MO treatment of the rats for the last 2 weeks of ethanol feeding completely reversed all the serum, hepatic parameters, and fatty liver changes. The increased maturation of sterol regulatory element-binding protein-1c in the liver by ethanol treatment was completely inhibited by treatment with MO. Therefore, MO may be a promising candidate for development as a therapeutic agent for ALD.ko_KR
dc.language.isoenko_KR
dc.publisherJAPANESE PHARMACOLOGICAL SOCko_KR
dc.subjectMagnolia officinalisko_KR
dc.subjectalcoholic fatty liverko_KR
dc.subjectsterol regulatory element-binding protein (SREBP)ko_KR
dc.subjectreactive oxygen speciesko_KR
dc.subjecttumor necrosis factor-alpha (TNF-alpha)ko_KR
dc.titleMagnolia officinalis Reverses Alcoholic Fatty Liver by Inhibiting the Maturation of Sterol Regulatory Element-Binding Protein-1cko_KR
dc.typeArticleko_KR
dc.contributor.AlternativeAuthor제영태-
dc.contributor.AlternativeAuthor김영철-
dc.contributor.AlternativeAuthor신영기-
dc.contributor.AlternativeAuthor이기용-
dc.contributor.AlternativeAuthor김윤철-
dc.contributor.AlternativeAuthor이병훈-
dc.contributor.AlternativeAuthor정길생-
dc.contributor.AlternativeAuthor성상현-
dc.identifier.doi10.1254/jphs.08182FP-
dc.citation.journaltitleJOURNAL OF PHARMACOLOGICAL SCIENCES-
dc.description.tc6-
Appears in Collections:
College of Pharmacy (약학대학)Dept. of Pharmacy (약학과)Journal Papers (저널논문_약학과)
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