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Expression of Bmi-1 protein in tumor tissues is associated with favorable prognosis in breast cancer patients

Cited 43 time in Web of Science Cited 44 time in Scopus
Authors
Choi, Young Jin; Choi, Yoon La; Cho, Eun Yoon; Shin, Young Kee; Kong, Gu; Kim, Jee Soo; Yang, Jung-Hyun; Nam, Seok Jin; Kim, Jung Han; Lee, Jeong Eon; Lee, Sang Jin; Hwang, Yu Kyeong; Sung, Ki Woong
Issue Date
2009-01
Publisher
Springer Verlag
Citation
BREAST CANCER RESEARCH AND TREATMENT, Vol.113, No.1, pp.83-93
Keywords
Bmi-1Prognostic markersImmunohistochemistryBreast cancerCell cycle regulator
Abstract
Purpose Abnormal expression of the cell cycle regulatory protein Bmi-1 has been studied in breast cancer, but the clinical relevance has not been fully elucidated. We studied the expression of Bmi-1 protein in breast cancer patients to define its clinical significance in breast cancer. Experimental Design Tissue microarrays were performed to evaluate the expression of Bmi-1 by immunohistochemistry in tumor tissues from 960 patients with stage I-III breast cancer. We assessed the relationship between the expression of Bmi-1 and pathologic prognostic indices as well as clinical long-term follow up outcome. Results Bmi-1 was expressed in 53.2% of breast cancer patients by immunohistochemistry, and the expression of Bmi-1 was significantly correlated with favorable prognostic indices at diagnosis. In univariate analysis, patients with Bmi-1 expression showed favorable relapse-free survival (88.6 +/- A 2.7% vs. 72.3 +/- A 4.3%, P = 0.041) and favorable overall survival (93.5 +/- A 2.2% vs. 82.6 +/- A 3.5%, P < 0.001) than patients without Bmi-1 expression. According to multivariate analyses, Bmi-1 expression was identified as independent prognostic factor for overall survival with a statistical significance (hazard ratio of Bmi-1 (-) patients compared to Bmi-1 (+) patients, 1.744; 95% CI, 1.013-3.003; P = 0.045). This correlation of Bmi-1 expression with favorable overall survival was maintained in patients underwent uniform chemotherapy, regardless of undergoing adjuvant chemotherapy. In a subset analysis according to ER status, Bmi-1 expression associated with favorable overall survival only in ER-positive patients. Conclusions Bmi-1 expression assessed with Immunohistochemistry may be associated with favorable overall survival in breast cancer patients, especially in patients with ER-positive breast cancer.
ISSN
0167-6806
Language
English
URI
http://hdl.handle.net/10371/81017
DOI
https://doi.org/10.1007/s10549-008-9909-4
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College of Pharmacy (약학대학)Dept. of Pharmacy (약학과)Journal Papers (저널논문_약학과)
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