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Effect of RGDS and KRSR peptides immobilized on silk fibroin nanofibrous mats for cell adhesion and proliferation

Cited 13 time in Web of Science Cited 15 time in Scopus
Authors
Kim, Jong Wook; Ki, Chang Seok; Park, Young Hwan; Um, In Chul; Kim, Hyun Jeong
Issue Date
2010
Publisher
Springer Verlag
Citation
Macromolecular Research, Vol.18, No.5, pp.442-448
Keywords
cell affinitysilk fibroinscaffoldnanofiberpeptide immobilization
Abstract
In this study, RGDS and KRSR peptides were immobilized onto electrospun silk fibroin (SF) nanofibrous mats by imide bond formation, and the cell affinities were evaluated as an immobilized SF scaffold. The MTT assay showed that cell adhesion and spreading of normal human dermal fibroblast (NHDF) occurs on SF nanofibrous mat with immobilized RGDS peptide in the early culture time (within 2-4 h after seeding). On the other hand, the KRSR peptide was more effective on normal human osteoblasts (NHOst). Therefore, the cell adhesion peptides RGDS and KRSR are effective in improving cell adhesion, spreading and proliferation of specific cell types. Moreover, these effects depend on the peptide density. The performance of the SF nanofibrous mats with immobilized peptides may be enhanced as a scaffold for specific uses. ⓒ 2010 The Polymer Society of Korea and Springer Netherlands.
ISSN
1598-5032
Language
English
URI
http://hdl.handle.net/10371/81038
DOI
https://doi.org/10.1007/s13233-010-0514-0
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College of Dentistry/School of Dentistry (치과대학/치의학대학원)Dept. of Dentistry (치의학과)Journal Papers (저널논문_치의학과)
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