Publications
Detailed Information
Radiosurgery for Atypical and Anaplastic Meningiomas: Histopathological Predictors of Local Tumor Control
Cited 16 time in
Web of Science
Cited 16 time in Scopus
- Authors
- Issue Date
- 2012-12
- Publisher
- KARGER
- Citation
- STEREOTACTIC AND FUNCTIONAL NEUROSURGERY Vol.90 No.5, pp. 316-324
- Keywords
- 복합학 ; Radiosurgery ; Local tumor control ; Atypical meningioma ; Anaplastic meningioma ; Prognostic factor
- Abstract
- Objectives: We investigated the radiosurgical outcomes of patients with nonbenign meningiomas retrospectively and sought to identify prognostic factors for local tumor control after radiosurgery with an emphasis on histopathology. Methods: Between 1998 and 2010, 35 patients with 49 atypical or anaplastic meningiomas were treated with radiosurgery. The mean tumor volume and marginal irradiation dose were 3.5 cm(3) (range 0.3-25.3) and 16 Gy (range 12-21), respectively. Results: The actuarial local tumor control rates for patients with atypical meningiomas at 1, 2 and 3 years after radiosurgery were 78, 53 and 36%, respectively, whereas those for anaplastic meningiomas were 35% at 1 year and 10% at 2 years. Multivariate analysis revealed that the mitotic count (<= 8 per 10 high-power fields; HPF) and the MIB-1 proliferation marker labeling index (LI; <= 8%) were significant favorable prognostic factors for the radiosurgical outcomes of patients with nonbenign meningiomas (p = 0.014 and p = 0.012, respectively). Conclusions: Radiosurgery could be a treatment option for patients with atypical meningiomas, but more aggressive treatments are needed for those with anaplastic meningiomas. Histopathological factors such as mitotic count and MIB-1 LI are significant prognostic factors for the radiosurgical outcomes of patients with nonbenign meningiomas and should be considered before radiosurgery. Copyright (C) 2012 S. Karger AG, Basel
- ISSN
- 1011-6125
- Language
- English
- Files in This Item:
- There are no files associated with this item.
- Appears in Collections:
Item View & Download Count
Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.