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College of Dentistry/School of Dentistry (치과대학/치의학대학원)
Dept. of Dentistry (치의학과)
Journal Papers (저널논문_치의학과)
Directing the differentiation of human dental follicle cells into cementoblasts and/or osteoblasts by a combination of HERS and pulp cells
- Issue Date
- 2011-06
- Publisher
- SPRINGER
- Citation
- JOURNAL OF MOLECULAR HISTOLOGY Vol.42 No.42, pp. 227-235
- Keywords
- 복합학 ; Dental follicle cell ; Pulp cell ; HERS ; Cementum ; Alveolar bone
- Abstract
- It is known that the dental follicle (DF) consists
of progenitor cells that give rise to the cementum, periodontal
ligament, and alveolar bone; but little information
is available about the regulation of DF cell differentiation
into either cementogenic or osteogenic cell lineages for the
regeneration of diseased periodontal tissue. Here, we
investigated the roles of DF, Hertwigs epithelial root
sheath (HERS), and pulp cells in the cementum and during
alveolar bone formation. We cultured these cells; transplanted
them alone or in combination into immunocompromised
mice; and observed their effects at 6 and
12 weeks. Histological and immunohistochemical results
revealed that DF cells formed cementum-like tissues with
immunoreactivity to cementum-derived attached protein,
bone sialoprotein, type I collagen, and alkaline phosphatase.
In addition, HERS cells played a role in the induction
and maturation of cementum-like tissues formed by DF
cells. In contrast, implants of DF cells in the presence of
pulp cells led to the formation of bone-like tissues.
- ISSN
- 1567-2379
- Language
- English
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