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Zinc is Essential for NFI-C Signaling for the Regulation of Odontoblast Differentiation.
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Oh, Hyun-Jung | - |
dc.contributor.author | Lee, Hye-Kyung | - |
dc.contributor.author | Park, Su-Jin | - |
dc.contributor.author | Cho, Young-Sik | - |
dc.contributor.author | Bae, Hyun-Sook | - |
dc.contributor.author | Cho, Moon-Il | - |
dc.contributor.author | Park, Joo-Cheol | - |
dc.creator | 박주철 | - |
dc.date.accessioned | 2013-03-22T01:18:21Z | - |
dc.date.available | 2013-03-22T01:18:21Z | - |
dc.date.issued | 2012-03 | - |
dc.identifier.citation | JOURNAL OF CELLULAR BIOCHEMISTRY Vol.113 No.113, pp. 877-887 | - |
dc.identifier.issn | 0730-2312 | - |
dc.identifier.uri | https://hdl.handle.net/10371/81398 | - |
dc.description.abstract | Zinc is trace element essential for diverse metabolic and cellular signaling pathways for the growth, development, and maintenance. Zinc
deficiency is involved in bone malformations and oral disease. Mice deficient in zinc transporter Zip13 show connective tissue and skeletal disorders, abnormal incisor teeth, and reduced root dentin formation in the molar teeth and share a morphologically similar phenotype to nuclear factor I-C (NFI-C)-deficient mice. However, the precise function of zinc in NFI-C signaling-mediated odontoblast differentiation and dentin formation remains unclear. Here, we show that zinc stimulated the expression of metal transcription factor-1, but decreased NFI-C expression in odontoblastic MDPC-23 cells. Zinc also enhanced the phosphorylation of Smad2/3 (p-Smad2/3) and increased the binding efficiency of NFI-C and p-Smad2/3 in the cytoplasm. In contrast, zinc deficiency resulted in the accumulation of NFI-C into nucleus. Consequently, NFI-C had the biologic properties of a transcription factor, including DNA binding affinity for metallothionein-1 and the dentin sialophosphoprotein (DSPP) promoter, and transcriptional activation of the DSPP gene. Furthermore, zinc deficiency condition promoted DSPP expression in odontoblasts and dentin mineralization, while zinc sufficiency condition decreased DSPP expression and slightly delayed dentin mineralization. These data suggest that zinc equilibrium is required for odontoblast differentiation and dentin formation during dentinogenesis through the nuclear accumulation and modulation of NFI-C. | - |
dc.language.iso | en | en |
dc.publisher | WILEY-LISS | en |
dc.subject | 복합학 | en |
dc.subject | ZINC | - |
dc.subject | NFI-C | - |
dc.subject | DENTIN | - |
dc.subject | ODONTOBLAST | - |
dc.subject | DIFFERENTIATION | - |
dc.title | Zinc is Essential for NFI-C Signaling for the Regulation of Odontoblast Differentiation. | en |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 오현정 | - |
dc.contributor.AlternativeAuthor | 이혜경 | - |
dc.contributor.AlternativeAuthor | 박수진 | - |
dc.contributor.AlternativeAuthor | 조영식 | - |
dc.contributor.AlternativeAuthor | 배현숙 | - |
dc.contributor.AlternativeAuthor | 조문일 | - |
dc.contributor.AlternativeAuthor | 박주철 | - |
dc.description.srnd | OAIID:oai:osos.snu.ac.kr:snu2012-01/102/0000042428/2 | - |
dc.description.srnd | SEQ:2 | - |
dc.description.srnd | PERF_CD:SNU2012-01 | - |
dc.description.srnd | EVAL_ITEM_CD:102 | - |
dc.description.srnd | USER_ID:0000042428 | - |
dc.description.srnd | ADJUST_YN:N | - |
dc.description.srnd | EMP_ID:A077448 | - |
dc.description.srnd | DEPT_CD:861 | - |
dc.description.srnd | CITE_RATE:2.868 | - |
dc.description.srnd | FILENAME:Zinc NFI-C 2012-03.pdf | - |
dc.description.srnd | DEPT_NM:치의학과 | - |
dc.description.srnd | EMAIL:jcapark@snu.ac.kr | - |
dc.description.srnd | SCOPUS_YN:Y | - |
dc.description.srnd | CONFIRM:Y | - |
dc.identifier.srnd | 2012-01/102/0000042428/2 | - |
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