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Association Between Metabolic Syndrome and Helicobacter pylori Infection Diagnosed by Histologic Status and Serological Status.
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- Authors
- Issue Date
- 2012-11
- Publisher
- Lippincott, Williams & Wilkins
- Citation
- JOURNAL OF CLINICAL GASTROENTEROLOGY Vol.46 No.10, pp. 840-845
- Keywords
- 복합학 ; Helicobacter pylori ; metabolic syndrome ; serology
- Abstract
- Goals: We aimed to simultaneously evaluate the association between
metabolic syndrome and Helicobacter pylori (HP) infection
diagnosed histologically and serologically in a large number of
healthy Korean adults.
Background: Serological positivity for HP does not necessarily indicate
current infection. No study to date has compared the association
between metabolic syndrome and HP infection diagnosed
by histologic and serological status.
Study: HP status was ascertained histologically and serologically in
healthy Korean adults who underwent comprehensive health
screening in a private health screening center in Korea. Metabolic
syndrome was defined according to the International Diabetes
Federation definition. Multivariate logistic analyses were performed,
after adjusting for potential confounders, including age,
sex, smoking, alcohol consumption, and income level.
Results: A total of 5889 subjects were included in the analysis. The
metabolic syndrome was more strongly associated with histologic
positivity for HP [adjusted odds ratio (aOR)=1.26; 95% confidence
interval (CI), 1.08-1.48] than serologic positivity (aOR=
1.12, 95% CI, 0.95-1.32), after adjusting for age, sex, smoking
status, alcohol consumption, and economic status.
Conclusions: The stronger association between metabolic syndrome
and histologic positivity than serological positivity suggests that the
effects of HP infection on the pathogenesis of cardiometabolic
outcomes may be reversible. Further prospective studies are
needed.
- ISSN
- 0192-0790
- Language
- English
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