토끼에 있어서 실혈, 과잉수혈 및 에피네프린으로 일어나는 조직 혈액량분포의 변화

Abstract

Variations of red cell volume and tissue blood volume were measured in 52 nembutalized rabbits by means of ere1 -labeled red blood cell technique. Animals were divided into 4 groups: the first was control group consisted of II rabbits. the second group (14 rabbits) was hemorrhaged 33% of total blood volume within 5 minutes. the third group (15 rabbits) was over-transfused amounting 34% of normal pretransfusion volume, and in the fourth group epinephrine was injected intravenously. The following results were obtained. 1. The normal red blood cell volume in rabbits was 1.8i±0.12 ml/lOO grn body weight. Total blood volume was 5.11±0.32% body weight. Tissue blood volume was highest in lung (476 ,ul/gm). Tissue blood volume values in other tissues were: spleen 218, liver 133. and kidney 117 ,u!/gm. The other tissues examined contained less than 100 ,ul/gm tissue blood volume. 2. In acute hemorrhage there appeared the decrease in hematocrit. red cell volume. total volume and tissue blood volume. Tissue blood volume decrement in lung showed the highest value ranging 48% as compa-red to the control group. Liver showed a 46% decrement. Skeletal muscle showed little decrement. Blood was mobilized chiefly from lung and liver in acute hemorrhage. 3. In over- transfusion there was a diffuse and even increment of tissue blood volume in various organs. Liver and skeletal muscle. however. showed high value of increase in tissue blood volume. 4. In the epinephrine administered rabbits. there were incrases in red cell volume, total blood volume and tissue blood volume.The increase in tissue blood volume was highest in spleen, e.g., 550% as compared to the preinjection values. Tissue blood volume incre ased also in liver and skeletal muscle and decreased in lung and bone.