개의 작은창자에서 본 포도당의 흡수 기전
Mechanism of Glucose Absorption From Small Intestine of Dogs

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서울대학교 의과대학
Seoul J Med 1964;5(3):31-38
One intestinal loop of 20 em in length was made by
ligating both ends of the loop of jejenum in 15 mongrel
dogs. The canule was placed into mesenteric vein
draining the intestinal loop.
20 cc of saline containing 200 mg% glucose was
incubated for 20 minutes in each intestinal loop.
Concentration gradient was made across the bloodlumen
barrier by injecting 50% glucose into the
jugular vein. According to the magnitude of glucose
concentration gradient, experiment was grouped into
three. Concentration gradient across blood-lumen
barrier averaged-l-LlLz mgs; in the first group.+16.4
mg% in the second group and +60.2 mg% in the
third group. The results were as follows:
1) True glucose absorption rate, represented by
disappearance rate of glucose from the incubation
medium, increased with the increment of concentration
gradients, i.e., the rate was 93.6±3. 3 mg/
hr /loop in the first group. 71.7±2.0 mg/hr/loop in
the second, and 62.9±4.9 mg/hr/loop in the third
Apparent glucose absorption rates. represented by
appearance rate of glucose in the venous blood, were
relatively constant in each group. i.e., the rate was
34.2±1.6 mg/hr/loop in the first group, 35.4±1.8 mg/
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hr/Ioop in the second group, and 33.2±1.8 mg/hr/loop
in the third group. Hence the apparant glucose absorption
rates constituted less than 50% of true glucose
absorption rates.
2) Lactate appearance rates were 35.9±2.6 mg/hr/l
oop in the first group. 25.1±4.0 mg/hr/Ioop in the
second group, and 14.9±0.62 mg/hr/Ioop in the
third group. Lactate appearance rates increased
with increment of concentration gradients as in
the case of true glucose absorbtion rates. Appearance
rates of pyruvic acid was negligible as compared
with that of lactac acid.
3) Oxygen consumption rates were 30.3±2.86 cc/hr,'
oop in the first group, 30.2±1.65 cc/hr/Ioop in
the second group, and 26.9± 1.43 cc/hr/Iooo. These
rates were relatively constant in each group regardless
of change in concentration gradients.
4) 76.4% of true glucose abrorption rates was recovered
from the venous blood in the forms of glucose.
lactate, and pyruvate in the first group, 77.7% in
the second group, and 86.4% in the third group.
These data suggest that, in dog intestine, glucose
absorption is carried out partly by active mechanism
and partly by diffusion. Glucose transported through
active mechanism appears to be absorbed in the
form of glucose molecules, whereas glucose transported
through diffusion seems to be absorbed in the degraded
form of lactate or pyruvate.
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College of Medicine/School of Medicine (의과대학/대학원)Dept. of Medicine (의학과)The Seoul Journal of MedicineThe Seoul Journal of Medicine Vol. 05 No.3 (1964)
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