은행성분 Bilobol의 화학적 및 약리학적 연구

Abstract

Flesh fruits of Ginkgo biloba 1. is induced often intensive vesicular skin inflammation. This vesicular skin inflammation is very similar to those induced by urushiol. In chemical structure of bilobol which is as known vesicular skin inflammatory components in flesh fruits of Ginkgo biloba 1. is pentadecenyldihydroxyphenol. This chemical structure is also resemble to constituents of urushiol. With a view to clarifying the chemical and pharmacological properties of bilobol, a component extract from the flesh of Ginkgo biloba Linne fruits, the author has conducted a series of experiment which led to the following conclusions: 1. Bilobol had a paralytic effect upon isolated rabbit intestines, while it exercised a contractive action upon the isolated uterus. 2. Bilobol did not produce any noticeable pharmacological effect upon frog heart even at a high dosage to 500mg/Kg. 3. LD50 of bilobol upon mouse was measured at 761mg/Kg. 4. Bilobol administration produced a transitional hypotensive effect upon rabbits. A repeated administration of bilobol produced tachyphylaxis. Bilobol administration produced a evidently increase effect upon rabbit respiration. 5. Capillary vessel permeability of bilobol appeared to be strongest in guinea pigs, followed by rats and rabbits in order of strength. 6. Edema resulting from administration of bilobol was markedly inhibited by chlorpheniramine maleate but not by BOL-148. 7. Histamine release by bilobol in lower extremities irrigation in rats started at bilobol O.lmg. and reached a maximum at bilobol 0.5mg. 8. Administration of bilobol did not produce any recognizable increase of 5-hydroxyindol acetic acid content of rat urine.