Glycyrrhizin 유도체인 2-Acetoxy 11-Keto 30-Acetoxymethyl Keto Oleanenic Acid와 부신피질 Hormone 분비와의 관계
Relation between Pharmacological Effects of 2-Acetoxy 11-Keto 30-Acetoxymethyl Keto Oleanenic Acid and Adrenocortical Secretions

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서울대학교 의과대학
Seoul J Med 1964;5(4):17-29
It is a known fact that two molecules of glucuronic
acid combined with glycyrrhetinic acid make up the
chemical structure of glycyrrhizin, main principle of
"Kamcho" or Glycyrrhiza glabra, etc., while the structure
of glycyrrhetinic acid, a poly terpene compound,
resembles that of phenantherene nucleus of steroid,
hormone series. In view of the pharmacological similarity
between glycyrrhetinic acid and steroid hormones,
the author conducted a series of experiment to
.confirrn the pharmacological action of 2-Acetoxy 11-
Keto ,d12:13 30-Acetoxymethyl Keto Oleanenic acid, a
derivative of glycyrrhizin, which has an even more
closer structure to steroid hormones, obtaining the
following conclusions:
1. After a successive administration of AMKOA for
7 days, the blood picture of rats revealed an increase
of red blood corpuscles and decrease of white blood
corpuscles. It also revealed that lymphocytes and
eosinophils were decreased, while neutrophils were
2_ In normal rats a successive administration of AM
KOA for 3 days resulted in the decrease in the
number of circulating eosinophils. No decrease
was noticed in adrenalectomized rats.
3. After a successive administration of AMKOA for
7 days sugar content in rat urine appeared to be
increased, while nitrogen content indicated no increase
of any significance, in contrast with the
control group.
4. A successive AMKOA administration seemed to
produce under histamine stress an increase in
adrenal ascorbic acid content and in adrenal cholesterol
content, compared with the control groups.
5. A successive administration of AMKOA for 7 days
resulted in an increase of potassium content in
rat urine and a decrease of sodium content.
6. A 7 day administration of AMKOA was followed
by a slight decrease in 17-Ketosteroid content of
rat urine, with no significance recognizable In
7. A 7 day administration of AMKOA produced no
difference in hypotensivity of the adrenalectomized
rats under histamine stress from the control group,
In the group of adrenalectomized rats previously
treated with cortisone and DCA an evident inhibition
of hypotension was observed.
8. AMKOA had an inhibitory effect upon liver corti·
coid metabolism in isolated livers, by paper chromatography.
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College of Medicine/School of Medicine (의과대학/대학원)Dept. of Medicine (의학과)The Seoul Journal of MedicineThe Seoul Journal of Medicine Vol. 05 No.4 (1964)
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