실험적 콩팥성 고혈압에 있어서 기관의 무게, 밀도 및 콜레스테롤 함유량의 변화

Abstract

Organ weight (% ratio to body weight). density and total cholesterol content were determined in experimental renal hypertensive rats. Encapsulation of bilateral kidneys with gause soaked with 20% cellulose acetate was 7 performed. The ensuing hypertension appeared after 40 days or mere and arterial bleed pressure reached to 180 mmHg at highest in about one-half of animals of which kidneys were encapsulated. The remaining rats which showed no elevation of arterial blocd pressure served as the control animals. The following results were obtained. 1. The ratio of organ weight to total body weight showed a general increase in the hypertensive rats. In heart and liver there were good correlations between arterial blood pressure and ratio of organ weight to bedy weight. The coefficient of correlation was r=0.64 and 1'=0.69 in heart and liver. respectively. 2 Density was highest in adrenals showing 1. 157 and lowest in cerebrum showing 1.044. The values of other organs were; spleen: 1.072. liver: 1.071. kidney: 1.062, and heart: 1.059. The organs which showed a variation in density in hypertension were kidney and liver. In kidney. density decreased as arterial blood pressure was elevated and the coefficient of correlation between the two was r= 0.46. In liver. density increased in the hypertensive rats showing a coefficient of correlation being r=0.15. 3. Total cholesterol content in plasma was 93 mg% .and in adrenals this amounted to 2640 mg% In renal hypertensive rats total cholesterol content of kidney decreased. The coefficient of correlation between arterial bleod pressure and kidney cholesterol content was r=-0.66. In adrenals, the hypertensive rats showed an increase in total cholesterol content (r=0.48.) and reached to the value of 3782 mg% 4. The interrelationships between organ weight, organ volume, density of varying composition of organs in renal hypertension were discussed.