Browse

Differential inhibition of transmembrane 4 L six family member 5 (TM4SF5)-mediated tumorigenesis by TSAHC and sorafenib.

Cited 12 time in Web of Science Cited 13 time in Scopus
Authors
Lee, Sin-Ae; Lee, Mi-Sook; Ryu, Hyung Won; Kwak, Tae Kyoung; Kim, Hyeonjung; Kang, Minkyung; Jung, Oisun; Kim, Hyun Jeong; Park, Ki Hun; Lee, Jung Weon
Issue Date
2011-02
Publisher
Landes Bioscience
Citation
CANCER BIOLOGY & THERAPY Vol.11 No.3, pp. 330-336
Keywords
자연과학contact inhibitionanti-tumorigenic reagentanti-tumorigenic reagentsorafenibTM4SF5
Abstract
Two separate clinical studies of advanced hepatocarcinoma patients recently reported that the multikinase inhibitor
sorafenib (nexavar) could extend survival of the patients only by 2–3 months. We also previously demonstrated that
4'-(p-toluenesulfonylamido)-4-hydroxychalcone (TSAHC) blocks the multilayer growth and migration mediated by
TM4SF5, which is highly expressed in approximately 80% of Korean hepatocarcinoma patients. Therefore, we wondered
how TSAHC might be different from sorafenib to deal with hepatocarcinoma in terms of the therapeutic characteristics
including specificity for TM4SF5. TM4SF5 is previously shown to mediate tumorigenesis through cytosolic p27Kip1-
mediated inactivation of RhoA, epithelial-mesenchymal transition, multilayer growth, migration, invasion and tumor
angiogenesis. In this study, TSAHC and two derivatives showed similar antagonistic activities against TM4SF5-mediated
signaling and multilayer growth in vitro and anti-tumorigenic activity even in early stages of TM4SF5-mediated tumor
formation in nude mice. Meanwhile, sorafenib was only effective much later in tumorigenesis in vivo and affected in vitro
proliferation in a TM4SF5-independent manner. Altogether, these observations suggest that TSAHC may be a promising
anti-tumorigenic reagent, especially against TM4SF5-mediated hepatocarcinoma.
ISSN
1538-4047
Language
English
URI
http://hdl.handle.net/10371/82065
DOI
https://doi.org/10.4161/cbt.11.3.14099
Files in This Item:
There are no files associated with this item.
Appears in Collections:
College of Pharmacy (약학대학)Dept. of Pharmacy (약학과)Journal Papers (저널논문_약학과)
  • mendeley

Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse