동종 급 이종 위점막조직의 반복주사에의한 백서 위병변에 관한 실험적 연구
An Experimental Study on Gastric Lesions in Rats Induced by Repeated Injections of Homologous and Heterologous Gastric Mucosa with Adjuvant

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서울대학교 의과대학
Seoul J Med 1967;8(3):21-39
An experimental study on gastric lesions in rats induced
by repeated injections of homologous and heterologous
gastric mucosal suspension with Freund's complete adjuvant
is made, as an attempt to produce immunological gastritic
changes and clarify the nature and significance of this
type of lesion as a morphological viewpoint, concerning
to a certain human chronic gastric disorders.
Followings are the results:
1. A reliable pathologic alteraton of gastric mucosa is
only observed in the group of animals that were injected
with rat gastric mucosal suspension with adjuvant. Ten
from fifteen animals reveal apparent and significant
deere ase in number of parietal cells, slight atrophic
mucosa, and increased number of mast cells, aside from
enhanced exudative inflammatory reaction in the glandular
portion of the gastric mucosa.
2. Even though are present difficulty to correlate
decreased parietal cell population with inflammatory
reaction, there are some evidences to suggest disappearance
of parietal cell being followed by atrophic mucosa,
at least in long term group.
3. Mild to moderate increase in number of mast cells
is observed, particularly in animals having considerable
decrease in population of parietal cells.
4. Aside from the above alterations, are encountered
irregularity of epithelia, destruction of gastric glands,
hyperplasia of foveolar layer, edema, congestion, active
lymphoid follicles with plasmocytic zone, intestinalization,
and fibrosis of muscularis mucosae. Squamous eqithelial
mucosa is devoid of any recognizable alteration.
5. There are observed mild focal thyroiditis in 2 from
15 animals, having notable decrease in population of
parietal cells.
6. Two characteristic systemic changes were observed
in groups of animals received either adjuvant alone or
with tissue suspensions; the one is non-caseous granuloma
formation in the injected site of skin, lungs, liver,
kidneys, adrenals and Iymphnodes; the another is marked
hyperplasia of reticuloendothelial cells of spleen, lymph
nodes, bone marrow, and liver, with enhanced infiltration
of plasma cells and lymphocytes.
From the above morphologic features, the experimental
gastric lesions presently described show many similarities
to those of chronic gastritis and/or chronic atrophic
gastritis, and it is suggested that an immunological
process may be concerned in one of the pathogenic
pathway of human chronic atrophic gastritis.
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College of Medicine/School of Medicine (의과대학/대학원)Dept. of Medicine (의학과)The Seoul Journal of MedicineThe Seoul Journal of Medicine Vol. 08 No.3 (1967)
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