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Plasma membrane calcium ATPase regulates bone mass by fine-tuning osteoclast differentiation and survival.
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Hyung Joon | - |
dc.contributor.author | Prasad, Vikram | - |
dc.contributor.author | Hyung, Seok-Won | - |
dc.contributor.author | Lee, Zang Hee | - |
dc.contributor.author | Lee, Sang-Won | - |
dc.contributor.author | Bhargava, Aditi | - |
dc.contributor.author | Pearce, David | - |
dc.contributor.author | Lee, Youngkyun | - |
dc.contributor.author | Kim, Hong-Hee | - |
dc.creator | 이장희 | - |
dc.date.accessioned | 2013-04-22T04:25:45Z | - |
dc.date.available | 2013-04-22T04:25:45Z | - |
dc.date.issued | 2012-12 | - |
dc.identifier.citation | JOURNAL OF CELL BIOLOGY Vol.199 No.7, pp. 1145-1158 | - |
dc.identifier.issn | 0021-9525 | - |
dc.identifier.uri | https://hdl.handle.net/10371/82231 | - |
dc.description.abstract | The precise regulation of Ca2+ dynamics is crucial
for proper differentiation and function of osteoclasts. Here we show the involvement of plasma membrane Ca2+ ATPase (PMCA) isoforms 1 and 4 in osteoclastogenesis. In immature/undifferentiated cells, PMCAs inhibited receptor activator of NF-B ligand–induced Ca2+ oscillations and osteoclast differentiation in vitro. Interestingly, nuclear factor of activated T cell c1 (NFATc1) directly stimulated PMCA transcription, whereas the PMCA-mediated Ca2+ efflux prevented NFATc1 activation, forming a negative regulatory loop. PMCA4 also had an anti-osteoclastogenic effect by reducing NO, which facilitates preosteoclast fusion. In addition to their role in immature cells, increased expression of PMCAs in mature osteoclasts prevented osteoclast apoptosis both in vitro and in vivo. Mice heterozygous for PMCA1 or null for PMCA4 showed an osteopenic phenotype with more osteoclasts on bone surface. Furthermore, PMCA4 expression levels correlated with peak bone mass in premenopausal women. Thus, our results suggest that PMCAs play important roles for the regulation of bone homeostasis in both mice and humans by modulating Ca2+ signaling in osteoclasts. | - |
dc.language.iso | en | en |
dc.publisher | Rockefeller University Press | en |
dc.subject | 의약학 | en |
dc.title | Plasma membrane calcium ATPase regulates bone mass by fine-tuning osteoclast differentiation and survival. | en |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 김형준 | - |
dc.contributor.AlternativeAuthor | 형석원 | - |
dc.contributor.AlternativeAuthor | 이장희 | - |
dc.contributor.AlternativeAuthor | 이상원 | - |
dc.contributor.AlternativeAuthor | 이영균 | - |
dc.contributor.AlternativeAuthor | 김홍희 | - |
dc.identifier.doi | 10.1083/jcb.201204067 | - |
dc.description.srnd | OAIID:oai:osos.snu.ac.kr:snu2012-01/102/0000026258/8 | - |
dc.description.srnd | SEQ:8 | - |
dc.description.srnd | PERF_CD:SNU2012-01 | - |
dc.description.srnd | EVAL_ITEM_CD:102 | - |
dc.description.srnd | USER_ID:0000026258 | - |
dc.description.srnd | ADJUST_YN:N | - |
dc.description.srnd | EMP_ID:A076310 | - |
dc.description.srnd | DEPT_CD:861 | - |
dc.description.srnd | CITE_RATE:10.264 | - |
dc.description.srnd | FILENAME:J Cell Biol-2012-Kim-ATPase.pdf | - |
dc.description.srnd | DEPT_NM:치의학과 | - |
dc.description.srnd | EMAIL:zang1959@snu.ac.kr | - |
dc.description.srnd | SCOPUS_YN:Y | - |
dc.description.srnd | CONFIRM:Y | - |
dc.identifier.srnd | 2012-01/102/0000026258/8 | - |
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