포도구균 및 대장균 혼합감염증에 있어서 도입경로의 차이가 미치는 영향에 관한 실험적연구

Abstract

It is well known that the different inoculation routes might produce quite different outcome of infections. However, comparisons of microbial virulences in different inoculation routes have been done so far by inoculating single species of microorganisms. Lately reports were published that the relative incidence of mixed infections increased considerably. Thus, it was conceived worthwhile to study the influences of the different inoculation routes on the experimental mixed infections. Staph. au reus and Es. coli were cultivated and inoculated into rabbits ear vein and peritoneal cavity, mixed or separately. Viable units of both microbial species in the heart blood and bladder urine were followed. Results were summarized as follows: 1. When the suspensions of Staph. aureus and Es. coli were mixed and inoculated intravenously; The viable units of staphylococci in the blood stream decreased rather slowly during the period of 3hours to 7days of infction. The viable units of staphylococci in the bladder urine increased sharply until 3-to 5days of infection and decreased later on. Small number of colon bacilli were recovered intermittently from the blood stream. The viable units of colon bacilli in the urine showed some increase until Iday after inoculation, followed hy no noticiable increase or decrease until 3day, and then showed marked increase until 7day of infection. 2. When the suspension of Staph. au reus and Es. coli were mixed and inoculated intraperitoneally ; From the blood stream no viable unit of staphylococci or colon bacilli was recovered through the 7days of observation. 9 Viable units of staphylococci in the urine showed some increase until 2nd day and then no noticiable increase or decrease until 7th day. Duringl to 3days of infection small number of colon bacilli were recovered from the urine, but could not be recovered after 3to 5days. 3. When the staphylococci were inoculated intravenously and colon bacilli intraperitoneally; The viable units of staphylococci in the blood showed sharp increase for 1 to 2 days and after that no noticiable decrease or increase until 7th day. The viable units of staphylococci in the urine showed sharp increase for 1 to 3days and no noticiable incroase or decerase until 7th day. Except very small number of colon bacilli ater 3hour, no colon bacillus could be recovered through 7days. After 2days the colon bacilli in the utine increased markedly until 5th and decreased. 4. When the colon bacilli were inoculated intravenously and the staphylococci intraperitoneally; No staphylococcus was recovered from the blood through 7days of observations, but small number of staphylocecci were recovered sporadiccally from the urine. Small number of colon bacilli were recovered from the blood persistently. Viable units of colon bacilli in the urine increased sharply for 1 to 2 days. followed no noticiable increase ordecrease until 5th day, and then decreased.