Euthyroidism 및 Hyperthyroidism 환자 혈청단백의 Agar Gel Electrophoretic Analysis

Abstract

1) An agar gel electrophoresis was carried out in order to elucidate the serum protein patterns derived from 4 cases of nontoxic goiters (euthyroidism) and 13 cases of toxic goiters (hyperthyroidism). 2) The serum protein patterns of nontoxic goiters (Table D showed in general remarkable increase of globulin. especially of gamma globulin in cost of albumin which is distinctly decreased. presumably owing to a hypofunction or and dysfunction of the thyroid caused by its primary disease. 3) Those of toxic goiters contained a good deal of varieties in the relative percentages of their fraction. Following points are thought to be noticeable: (a) Albumin remained normal or in slightly changed values in 10/13 of the cases tested. (b) Alpha-I failed to be separated in 6/13 of the cases. (c) Alpha-S increased more than normal in 12/13 of the cases. (d) The elevation of the amount of beta was aproved only in 4/13 of the cases. (e) Gamma increased more than normal in 11/13 of the cases tested. 4) The changes enumerated above in 2) and 3) are by no means specific for euthyroidism and hyperthyroidism respectively.