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Osseointegration of Anodized Titanium Implants Coated with Poly(lactide-co-glycolide)/Basic Fibroblast Growth Factor by Electrospray
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Su Young | - |
dc.contributor.author | Koak, Jai Young | - |
dc.contributor.author | Heo, Seong Joo | - |
dc.contributor.author | Kim, Seong Kyun | - |
dc.contributor.author | Nam, Seung Yeon | - |
dc.contributor.author | Lee, Seung Jin | - |
dc.date.accessioned | 2013-04-30T08:57:42Z | - |
dc.date.available | 2013-04-30T08:57:42Z | - |
dc.date.issued | 2010-04 | - |
dc.identifier.citation | International Journal of Oral and Maxillofacial Implants, Vol.25, No.2, pp. 315-320 | ko_KR |
dc.identifier.issn | 0882-2786 | - |
dc.identifier.uri | https://hdl.handle.net/10371/82360 | - |
dc.description.abstract | Purpose: The purpose of this study was to evaluate the effect of basic fibroblast growth factor (bFGF) in combination with a biodegradable polymer coated onto titanium implants. The implants were inserted in rabbit tibiae, and bone growth was examined by histomorphometric analysis. Materials and Methods: Forty-eight threaded anodized implants were inserted into the tibiae of 12 rabbits. After 12 weeks of healing, an evaluation was made by light microscopy and computerized image analysis. A total of 56 anodized titanium implants were prepared as follows: group 1 was anodized under 300 V; group 2 was anodized then coated with 0.02 mL poly(lactide-co-glycolide) (PLGA) nanoparticles; group 3 was anodized then coated with 0.02 mL PLGA/bFGF nanoparticles (10 ng bFGF); and group 4 was anodized then coated with 0.2 mL PLGA/bFGF nanoparticles (100 ng bFGF). Results: Nanosized particles were observed on the coated implant surfaces. The mean diameter of the nanoparticles was 268.6 +/- 93.2 nm. The mean boneto-implant contact (BIC) percentage in group 4 (44.7%) was significantly greater than that seen in groups 1 (31.4%) and 2 (33.6%) (P < .05). Conclusions: The results of this preliminary study show that coating a titanium implant with PLGA incorporated with bFGF by electrospray may stimulate bone formation adjacent to the surface of an implant inserted in bone. INT J ORAL MAXILLOFAC IMPLANTS 2010; 25: 315-320 | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | Quintessence Publishing | ko_KR |
dc.subject | anodized titanium | ko_KR |
dc.subject | poly(lactide-co-glycolide) | ko_KR |
dc.subject | histomorphometric analysis | ko_KR |
dc.subject | electrospray | ko_KR |
dc.subject | fibroblast growth factor | ko_KR |
dc.title | Osseointegration of Anodized Titanium Implants Coated with Poly(lactide-co-glycolide)/Basic Fibroblast Growth Factor by Electrospray | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 이수영 | - |
dc.contributor.AlternativeAuthor | 곽재영 | - |
dc.contributor.AlternativeAuthor | 허성주 | - |
dc.contributor.AlternativeAuthor | 김성균 | - |
dc.contributor.AlternativeAuthor | 남승연 | - |
dc.contributor.AlternativeAuthor | 이승진 | - |
dc.citation.journaltitle | INTERNATIONAL JOURNAL OF ORAL & MAXILLOFACIAL IMPLANTS | - |
dc.description.tc | 3 | - |
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