RAI에 대한 갑상선 흡수율 증진에 관한 연구

Abstract

The changes of thyroid J131 uptake in rabbits after ligating thyroidal vessels. fasting for 24-hours. X-Ray general irradiation and P.H.P.(parahydroxypropiophenone) administration are investigated. Total 135 female rabbits weighing between 1.01 kg and 1.32kg has been used for study. For the first group. thyroid vein. artery and. vein and artery are ligated in 45 rabbits. 15 in each. under general ether anaesthesia. After this procedure. 15,uc of J131 in 1cc of water solution is injected into abdomen alcavity. 24hour thyroid 1131 uptake is estimated by sc in-tillation counter. For the second group. 15 female rabbits are fasted for 24 hours and administered with 15,uc of lI31 in 1 cc water solution. 24hour thyroid lI31 uptake is measured. For the third group. 30 female rabbits are divided into 3 groups. 10 in each. Each subdivived groups are irradiated with 50 ria every other day for 5 days. On the end of irradiation 15,uc of lI31 is administered with 1 cc of water solution into abdominal cavity. 24 hour thyroid lI31 uptake is counted. For the 4th group. 30 female rabbits are subdivided into 3 groups. 10 in each. Each subdivided groups are administered with 50 mg. 100mg and 150 mg of P.H.P. daily for successive 5 days. Rabbits are put under rest for 5 days after drug administration and 15,uc of 1131 in 1 cc water solution is administered into abdominal cavity. 24hour thyroid lI31 uptake is measured. 15 rabbits without any treatment are used as a control group. The results are as follows. (1) In the group of thyroid vein ligation. there was 15% increase in thyroid lI31 uptake. However. there were little change in thyroid artery ligation and thyroid artery and Vein ligation group in comparison with control. (2) In the fasted group the thyroid lI31 uptake has decreased on the contrary to our expectation. (3) The irradiated group showed some increase in thyroid lI31 uptake. particularly in group of 100 ria daily dose. The increases are as follows. in l00r/a dose group from 16% to 26%. in 50r/a dose group from 16% to 20% and in 150ria dose group from 16% to 22%. (4) The animals being treated with P.H.P revealed some decreases in lI31 thyroid uptake. However there were no clear relationship between administered dose and decrease of uptake. It is noteworthy to mention that there were only a little variation of lI31 uptake in relation to animal individuality. (5) We have suggested some possibility of improvement in the treatment of hyperthyroidism and thyroid cancer by combining thyroid artery ligation along with lI31 administration. (6) The combination of thyroid vein ligation. X· Ray irradiation and lI31 administration may be more beneficial in the treatment of thyrotoxicosis.