직업적 급혈자의 빈혈에 관한 연구(제1보)

Abstract

The various hematological examinations on one hundred and fifty- three male donors. thirty five female donors and thirty donors with severe anemia who visited the Seoul National University Hospital Blood Bank and the National Blood Bank were carried out and the results are as follows: 1. In the majority of prefessional donors, who had donated blood even once a year, the values of hemoglobin, hematocrit and erythrocytes were decreased. The diversity from norma values became greater as the frequency of donation increased. 2. The whole blood specific gravity was lower as the frequency of donation increased, while the specific gravity of the plasma was almost unchanged. 3. The diminution of serum iron in the donors was most remarkable and appeared early while the anemia was only slight. The serum copper levels remained within normal limits. 4. The total serum proteins were not altered in cases of infrequent donation, but were decreased as the frequency of donation occurred. 5. Applying the pyrogen test to the donors, the hemopoietic function of the white blood corpuscle series in the bone marrow was found to be similar to that of the normal. 6. Bone marrow examination of the donors revealed the hemopoietic function to be normal, with hyperactivity present in the erythrocytic series. 7. The oral iron loading test demonstrated that iron was readily absorbed and that the anemia of the donors improved gradually with the administration of iron preparations. 8. The total acidity of the gastric juice of the donors with severe anemia due to repeated donations was lower than normal. 9. A remarkable decrease of serum iron as well as an increased unsaturated iron binding capacity in serum were observed in the professional donors. 10. The iron-deficient, microcytic and hypochromic anemia was provoked In almost all cases of the professional donors, unless bleeding was limited to three times a year in the male donors and to two times a year in the female donors. 11. In the female donors, the decrease of all hematological values were more marked and the anemia was provoked earlier than in the male donors. ia The author concludes that frequent blood donations should be avoided and that all prefessional donors should be given supplemental iron as a deficiency in this mineral is demonstrable in donors.