직업적 급혈자의 빈혈에 관한 연구(제2보)

Abstract

In order to observe iron metabolism in iron deficiency anemia, the ferrokinetics using Fe59 were studied in 22 professional donors, who had severe anemia due to repeated donations. The following results were obtained. As a control five healthy adult males were also studied. 1. All the donors had lower than normal values of erythrocytes, hemoglobin, hematocrit, and serum iron. 2. Plasma iron disappearance in all donors was shorter than that in normal adults. 3. Plasma iron turnover In the donors was nearly twice as rapid as that in the control group. 4. All donors had a higher utilization ratio than the control group, and the duration of time to reach the highest utilization ratio was shorter in the donors. 5. Red cell iron turnover in the donors was increased about twice that found the control group. 6. Plasma iron pool in the donors was about one half that found in the control group. 7. Daily iron pool turnover was increased four times in the donors. 8. The decrease in total red cell iron in the donors was more marked than that in the control group. 9. When the donors were in the anemic state due to repeated donations, the plasma volume in the anemic donors was increased and the red cell volume was decreased, but the total circulating blood volume was not markedly changed -normovolemic state of anemia. 10. In vivo radioactive iron uptake was no different in the donors and the controls, but radioactive iron absorption by the bone marrow was more rapid in the donors although levels quickly dropped lower than in normal adults. 11. It is concluded that the anemia of the professional donors is a typical Iron deficiency anemia.