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동맥경화증 성인에 관한 연구(제1보) : Studies on Pathogenesis of Atherosclerosis (Report I)

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Authors

강승호; 김숭원; 전성균

Issue Date
1961-06-01
Publisher
서울대학교 의과대학
Citation
Seoul J Med, Vol.2 No.1, pp. 59-62
Abstract
There are studies indicating a delayed increase In
the rate of hepatic biosynthesis of fatty acids in
whole-body X-irradiated albino rats, as indicated by
measurements of acetate-I-C 14 incorporation 1-3).
And, in particular, considerable augmentation of
cholesterol biosynthesis from acetate in the albino
rat liver and adrenals by exposure of the animals to
X-irradiation.,5) and also by injection of the detergent
Triton WR 13396) have been reported. On the
other hand, suppression of the biosynthetic rate was
obsevred in animals deprived of food for 24 to 48
hours7. 8) or when fed a cholesterol-enriched diet 9- 13)
or when administered 4-cholestenone14•15).
Thus, regulation of cholesterol homeostatis in ani·
mals by variation in the rate of cholesterol biosynthesis
appears to be primarily a function of the liver.
It is, therefore, quite natural to expect that radiant
energy absorbed in the liver tissue will no doubt
cause a significant disturbance with regard to homeostasis
of living cells. In addition to X-ray, the author
was interested in any alteration of cholesterol biosynthesis
caused by administration of ginseng extract,
carbon-tetrachloride and ethyl-alcohol to albino rats.
Though there are many steps not yet elucidated
regarding cholesterol biosynthesis from acetate, it is
postulated that three molecules of acetate combine
to form branched chain intermediates of six carbon,
which, in turn, yield by multiple condensationsqualen.
Squalen, in a later stage, is cyclized into lanosterol
which is, in turn, transformed into cholesterol.
The purpose of the present investigation was to
study the variation in the biosynthetic rate of cholesterol
in the liver after whole-body Xvirradiauon
and ginseng extract, carbon-tetrachloride and ethylalcohol
administration to albino rats compared with
that in normal rats by measuring the incorporation
rate of acetate-LCw into a cell free homogenate of
liver.
ISSN
0582-6802
Language
English
URI
https://hdl.handle.net/10371/8243
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