Hippocampus가 손상된 흰쥐의 갑상선기능
Thyroid Activity Following Hippocampal Ablation

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김철; 김창욱
Issue Date
서울대학교 의과대학
Seoul J Med 1961;2(3):83-85
The hippocampus was ablated through neocortex
in a group of male albino rats(hippocampus group).
Rats were also prepared in which only the portion of
neocortex over the hippocampus was ablated(neocortex
group). These rats together with normal control rats
were studied on their thyroid activity before and following
brain ablation in warm environment(28-30°C),
and then also under reduced room temperature(1416°
C). Following intraperitoneal administration of 10,uC
of carrier-free 1131, the radioactivity of the thyroid
was measured every morning and evening or every 24
hour for 120 to 144 hours. The thyroidal release rate
of 1131 was calculated taking the 48th hour radioactivity
as 100% and was expressed in the form of effective
half life, which served as an index of the thyroid
Under 28-30°C, the effective half life tended to
prolong after brain damage compared with that of
preoperative period both in hippocampus group(N: 8,
Mean±S.D. : 54.2±9.29 hr before, 72.6±23.10 after)
and also in neocortex group (N: 8, Mean±S.D.: 50.5
±8.24 hr before, 61.6±20.80 after). But the difference
was of dubious significance in hippocampus group(.05
<p<.10) and insignificant in neocortex group(p>.20).
Nor was there any significant difference between hippocampus
group and neocortex group as regards the
net increment of effective half life following brain lesion.
For reference, the mean effective half life of
three normal control rats under the same environment
throughout was 53.8 hr in the preoperative period,
and 51.6 hr in the postoperative period.
In another experiment, where hippocampus group,
neocortex group, and normal control group were subjected
to reduced room temperature(14-16°C), the
thyroid activity was found significantly accelerated in
all groups. The differences in the effective half life
among these three groups, however, were negligible
and statistically insignificant under low temperature
(N : 12 in each group, Mean±S.D.: 42.7±6.37 hr in
normal control group, 46.3±7.21 in hippocampus
group, and 43.2±5.83 in neocortex group). These
three groups had been equated as regards their thyroid
activity in the preoperative period under 28-30
The inferences from these data are that the hippocampus
and neocortex might exert slight, inconspicuous
facilitatory influence upon thyroid activity in
warm weather, but that these brain structures seems
to exert little influence upon accelerated thyroid function
in cold weather.
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College of Medicine/School of Medicine (의과대학/대학원)Dept. of Medicine (의학과)The Seoul Journal of MedicineThe Seoul Journal of Medicine Vol. 02 No.3 (1961)
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