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Poly(ester amine)-mediated, Aerosol-delivered Akt1 Small Interfering RNA Suppresses Lung Tumorigenesis

Cited 77 time in Web of Science Cited 80 time in Scopus
Authors
Xu, Cheng-Xiong; Jere, Dhananjay; Jin, Hua; Chang, Seung-Hee; Chung, Youn-Sun; Shin, Ji-Young; Kim, Ji-Eun; Park, Sung-Jin; Lee, Yong-Hoon; Chae, Chan Hee; Lee, Kee Ho; Beck, George R.; Cho, Chong-Su; Cho, Myung-Haing
Issue Date
2008
Publisher
American Thoracic Society
Citation
Am J Respir Crit Care Med 2008;178:60-73
Keywords
poly(ester amine)Akt1 siRNAlung cancerK-rasLA1 miceurethaneaerosol gene delivery
Abstract
RATIONALE: The low efficiency of conventional therapies in achieving long-term survival of patients with lung cancer calls for the development of novel therapeutic options. Recent advances in aerosol-mediated gene delivery have provided the possibility of an alternative for the safe and effective treatment of lung cancer. OBJECTIVES: To demonstrate the feasibility and emphasize the importance of noninvasive aerosol delivery of Akt1 small interfering RNA (siRNA) as an effective and selective option for lung cancer treatment. METHODS: Nanosized poly(ester amine) polymer was synthesized and used as a gene carrier. An aerosol of poly(ester amine)/Akt1 siRNA complex was delivered into K-ras(LA1) and urethane-induced lung cancer models through a nose-only inhalation system. The effects of Akt1 siRNA on lung cancer progression and Akt-related signals were evaluated. MEASUREMENTS AND MAIN RESULTS: The aerosol-delivered Akt1 siRNA suppressed lung tumor progression significantly through inhibiting Akt-related signals and cell cycle. CONCLUSIONS: The use of poly(ester amine) serves as an effective carrier, and aerosol delivery of Akt1 siRNA may be a promising approach for lung cancer treatment and prevention.
ISSN
1073-449X
Language
English
URI
http://hdl.handle.net/10371/8283
DOI
https://doi.org/10.1164/rccm.200707-1022OC
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College of Veterinary Medicine (수의과대학)Dept. of Veterinary Medicine (수의학과)Journal Papers (저널논문_수의학과)
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