SHERP

Analysis of Gene Expression in Mouse Alveolar Macrophages Stimulated with Quorum-Sensing Mutants of Vibrio vulnificus

Cited 0 time in webofscience Cited 0 time in scopus
Authors
Shin, Na-Ri; Lee, Deog-Yong; Yoo, Han Sang
Issue Date
2008
Publisher
Institute of Infectious Diseases
Citation
Jpn. J. Infect. Dis., 61, 402-406
Abstract
Bacterial pathogens manipulate host cells to promote pathogen survival and dissemination. In this study, microarray technology was used to identify the genes that are affected by the Vibrio vulnificus quorum-sensing genes, luxS and smcR. By comparing the expression profiles of mouse macrophage cell lines stimulated with either the parent strains or a luxS smcR mutant, differentially expressed genes were identified. The genes included those that affect host cell death, stress, signaling transduction, inflammation, and immune response. Macrophages stimulated with the luxS smcR mutant differentially expressed genes associated with removal of toxins, the complement pathway, regulation of cytokine expression, and antigen presentation, indicating that macrophages stimulated with the luxS smcR mutant induced an appropriate inflammation reaction and immune response for removal of bacteria. In summary, quorum-sensing in V. vulnificus could contribute to bacterial survival and increased pathogenesis by inducing a changed expression profile in macrophages.
ISSN
1344-6304
Language
English
URI
http://hdl.handle.net/10371/8296
Files in This Item:
Appears in Collections:
College of Veterinary Medicine (수의과대학)Dept. of Veterinary Medicine (수의학과)Journal Papers (저널논문_수의학과)
  • mendeley

Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse