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Risk assessment of the organophosphate pesticides isazofos and pyraclofos using a 21-day dietary toxicity study in Japanese quail .

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Authors
Seok, Seung-Hyeok; Park, Jong-Hwan; Cho, Sun-A.; Kim, Dong-Jae; Bae, Bo-Kyoung; Park, Jae Hak
Issue Date
2007-07-16
Publisher
Elsevier
Citation
Ecotoxicol. Environ. Saf. 71, 245-251
Keywords
Dietary toxicityJapanese quailIsazofosPyraclofos
Abstract
Six-week-old male and female Japanese quails (Coturnix japonica) received two organophosphate pesticides, isazofos and pyraclofos, for a 21-day dietary toxicity test, based on the OECD workshop report. During the treatment period, body weight and food consumption of the quail decreased with exposure to either isazofos or pyraclofos. Using the up-and-down procedure to determine the 50% mortality value, we found that the 21-day LC50 of isazofos and pyraclofos were 40 and 87 mg/kg body weight, respectively. Ataxia, salivation, diarrhea, ruffled feathers, and convulsions at a dead point were observed with both pesticides. The tips of the villi were necrotic in the high dosage groups of isazofos- and pyraclofos-treated quail. Based on these results, body weight, food consumption, clinical signs, and histopathological findings may be useful parameters for detecting the dietary toxicity associated with isazofos and pyraclofos exposure. In addition, Japanese quail could be an excellent bird model for monitoring the toxicological risks of pesticides in Korea.
ISSN
0147-6513
Language
English
URI
http://hdl.handle.net/10371/8307
DOI
https://doi.org/10.1016/j.ecoenv.2007.05.015
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College of Veterinary Medicine (수의과대학)Dept. of Veterinary Medicine (수의학과)Journal Papers (저널논문_수의학과)
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