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Serum Cystatin C Is a Major Predictor of Vancomycin Clearance in a Population Pharmacokinetic Analysis of Patients with Normal Serum Creatinine Concentrations

Cited 17 time in Web of Science Cited 20 time in Scopus
Authors
Chung, Jae-Yong; Jin, Sung-Joon; Yoon, Ji-Hyun; Song, Young-Goo
Issue Date
2013-01
Publisher
KOREAN ACAD MEDICAL SCIENCES
Citation
Journal of Korean Medical Science Vol.28 No.1, pp. 48-54
Keywords
복합학VancomycinCystatin CPharmacokineticsNONMEMTDM
Abstract
We developed a population pharmacokinetic model of vancomycin by integrating the effects of cystatin C and other demographic factors in a large population of Korean patients with normal serum creatinine concentrations to elucidate the precise role of serum cystatin C concentrations in the prediction of vancomycin clearance. A population pharmacokinetic model of vancomycin was developed using NONMEM software from a total of 1,373 vancomycin concentration measurements in 678 patients whose serum creatinine concentrations were lower than 1.2 mg/dL. Covariate selection revealed that cystatin C was the most influential factor and had negative influence ((-0.78)) in the relationship. Total body weight, sex, age, and serum creatinine were also significantly correlated with the clearance. The estimated intersubject variabilities of clearance and volume of distribution were 24.7% and 25.1%, respectively. A 14-fold difference in predicted trough concentrations was observed according to only cystatin C concentrations in a population of simulated individuals with median demographic characteristics. The use of serum cystatin C as marker of vancomycin clearance for more accurate predictions of serum vancomycin concentrations could be useful, particularly among patients with normal serum creatinine concentrations.
ISSN
1011-8934(Print)
1598-6357(Online)
Language
English
URI
http://hdl.handle.net/10371/83267
DOI
https://doi.org/10.3346/jkms.2013.28.1.48
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College of Medicine/School of Medicine (의과대학/대학원)Dept. of Medicine (의학과)Journal Papers (저널논문_의학과)
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