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Serum Cystatin C Is a Major Predictor of Vancomycin Clearance in a Population Pharmacokinetic Analysis of Patients with Normal Serum Creatinine Concentrations
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Chung, Jae-Yong | - |
dc.contributor.author | Jin, Sung-Joon | - |
dc.contributor.author | Yoon, Ji-Hyun | - |
dc.contributor.author | Song, Young-Goo | - |
dc.creator | 정재용 | - |
dc.date.accessioned | 2013-08-07T04:15:00Z | - |
dc.date.available | 2013-08-07T04:15:00Z | - |
dc.date.issued | 2013-01 | - |
dc.identifier.citation | Journal of Korean Medical Science Vol.28 No.1, pp. 48-54 | - |
dc.identifier.issn | 1011-8934(Print) | - |
dc.identifier.issn | 1598-6357(Online) | - |
dc.identifier.uri | https://hdl.handle.net/10371/83267 | - |
dc.description.abstract | We developed a population pharmacokinetic model of vancomycin by integrating the effects of cystatin C and other demographic factors in a large population of Korean patients with normal serum creatinine concentrations to elucidate the precise role of serum cystatin C concentrations in the prediction of vancomycin clearance. A population pharmacokinetic model of vancomycin was developed using NONMEM software from a total of 1,373 vancomycin concentration measurements in 678 patients whose serum creatinine concentrations were lower than 1.2 mg/dL. Covariate selection revealed that cystatin C was the most influential factor and had negative influence ((-0.78)) in the relationship. Total body weight, sex, age, and serum creatinine were also significantly correlated with the clearance. The estimated intersubject variabilities of clearance and volume of distribution were 24.7% and 25.1%, respectively. A 14-fold difference in predicted trough concentrations was observed according to only cystatin C concentrations in a population of simulated individuals with median demographic characteristics. The use of serum cystatin C as marker of vancomycin clearance for more accurate predictions of serum vancomycin concentrations could be useful, particularly among patients with normal serum creatinine concentrations. | en |
dc.language.iso | en | en |
dc.publisher | KOREAN ACAD MEDICAL SCIENCES | en |
dc.subject | 복합학 | en |
dc.subject | Vancomycin | - |
dc.subject | Cystatin C | - |
dc.subject | Pharmacokinetics | - |
dc.subject | NONMEM | - |
dc.subject | TDM | - |
dc.title | Serum Cystatin C Is a Major Predictor of Vancomycin Clearance in a Population Pharmacokinetic Analysis of Patients with Normal Serum Creatinine Concentrations | en |
dc.type | Article | - |
dc.author.alternative | 진성준 | - |
dc.author.alternative | 윤지현 | - |
dc.author.alternative | 송영구 | - |
dc.author.alternative | 정재용 | - |
dc.identifier.doi | 10.3346/jkms.2013.28.1.48 | - |
dc.citation.journaltitle | Journal of Korean Medical Science | - |
dc.description.srnd | OAIID:oai:osos.snu.ac.kr:snu2013-01/102/0000050045/1 | - |
dc.description.srnd | SEQ:1 | - |
dc.description.srnd | PERF_CD:SNU2013-01 | - |
dc.description.srnd | EVAL_ITEM_CD:102 | - |
dc.description.srnd | USER_ID:0000050045 | - |
dc.description.srnd | ADJUST_YN:Y | - |
dc.description.srnd | EMP_ID:A078941 | - |
dc.description.srnd | DEPT_CD:801 | - |
dc.description.srnd | CITE_RATE:.993 | - |
dc.description.srnd | FILENAME:vancomycin cystatin c model_jkms 2013.pdf | - |
dc.description.srnd | DEPT_NM:의학과 | - |
dc.description.srnd | EMAIL:mekka@snu.ac.kr | - |
dc.description.srnd | SCOPUS_YN:Y | - |
dc.description.srnd | CONFIRM:Y | - |
dc.identifier.srnd | 2013-01/102/0000050045/1 | - |
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